Kinetic models of metabolism that consider alternative steady-state solutions of intracellular fluxes and concentrations

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Supercritical water gasification (SCWG) is a promising technology to convert wet biomass to renewable natural gas. The present study sheds light on the chemical composition and the formation mechanism of coke deposits on a Ru/CNF catalyst during continuous ...

IntroductionDesulfitobacterium hafniense was isolated for its ability to use organohalogens as terminal electron acceptors via organohalide respiration (OHR). In contrast to obligate OHR bacteria, Desulfitobacterium spp. show a highly versatile energy meta ...

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AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...

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We explored a computational model of astrocytic energy metabolism and demonstrated the theoretical plausibility that this type of pathway might be capable of coding information about stimuli in addition to its known functions in cellular energy and carbon ...

Background Significant efforts have been made in building large-scale kinetic models of cellular metabolism in the past two decades. However, most kinetic models published to date, remain focused around central carbon pathways or are built around ad hoc re ...

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Modelling and analysis of biological systems is crucial in order to quantitatively explain and predict their behaviour. The importance of modelling in systems biology becomes even more evident when tackling complex, large systems. Approaches that rely on ...

Kinetic models of metabolism that consider alternative steady-state solutions of intracellular fluxes and concentrations

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Reconstruction and analysis of genome-scale metabolic networks in single organisms and microbial communities

Optimality principles for the analysis of biological processes across scales: From enzyme kinetics to microbiome dynamics

NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection

Multimodal transcriptomic atlases of mouse spinal cord injury

Modeling, analysis, and design of complex biological networks

Molecular reconstruction and simulation of the Neuron-Glia-Vasculature system

Engineering extracellular electron transfer for enhanced energy harvesting in microbial electrochemical devices

The nature of carbon deposits and their formation pathways during catalytic supercritical water gasification of glycerol

Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms

Statistical physics of periodic biological processes

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Role of the cystathionine beta-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome

Representing stimulus information in an energy metabolism pathway

The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

Computational tools and resources for designing new pathways to small molecules

Expanding biochemical knowledge and illuminating metabolic dark matter with ATLASx

Constraint-based metabolic control analysis for rational strain engineering

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

New and improved methods for integrated models of metabolism and gene expression

Modelling the Intracellular Environment under Uncertainty, from Post-translational Modification to Metabolic Networks