Publications associées à Bioengineering of morphologically and functionally accurate in vitro intestinal models

Publications associées (12)

Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution

Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves a ...

Springer Science and Business Media LLC2025

Structural investigations of brain and skin tissues in Parkinson's and related diseases, using correlative light and electron microscopy

Marta Di Fabrizio

Parkinson's disease (PD), Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) are neurodegenerative disorders collectively termed synucleinopathies, as they all present proteinaceous pathological aggregates of alpha-synuclein (aSyn) in the br ...

EPFL2025

NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice

Johan Auwerx

Background and aims: NAD+ (nicotinamide adenine dinucleotide) is a cosubstrate of the sirtuins (SIRT) that are activated upon caloric restriction. Supplementing NAD+ precursors such as nicotinamide riboside (NR) has been reported to extend life span and co ...

Elsevier2025

Bioconcentration Assessment of Three Cationic Surfactants in Permanent Fish Cell Lines

Kristin Schirmer

Cationic surfactants are used in many industrial processes and in consumer products with concurrent release into the aquatic environment, where they may accumulate in aquatic organisms to regulatoryly relevant thresholds. Here, we aimed to better understan ...

2024

Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

Bruno Lemaitre, Zongzhao Zhai

Amino acid availability is monitored by animals to adapt to their nutritional environment. Beyond gustatory receptors and systemic amino acid sensors, enteroendocrine cells (EECs) are believed to directly percept dietary amino acids and secrete regulatory ...

Nature Portfolio2024

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Giovanni D'Angelo, Francisco De Magalhães Sarmento Ribeiro De Mesquita, Oksana Andrei Sergeeva, Laura Capolupo, Audrey Geneviève Chuat, Muhammad Umair Anwar, Triana Amen

To promote infections, pathogens exploit host cell machineries such as structural elements of the plasma membrane. Studying these interactions and identifying molecular players are ideal for gaining insights into the fundamental biology of the host cell. H ...

Cell Press - Elsevier2022

Comorbidity clusters associated with newly treated type 2 diabetes mellitus: a Bayesian nonparametric analysis

Fernando Perez Cruz

Type 2 diabetes mellitus (T2DM) is associated with the development of chronic comorbidities, which can lead to high drug utilization and adverse events. We aimed to identify common comorbidity clusters and explore the progression over time in newly treated ...

Nature Research2022

A Fetal Brain magnetic resonance Acquisition Numerical phantom (FaBiAN)

Tobias Kober, Tom Hilbert, Thomas Yu

Accurate characterization of in utero human brain maturation is critical as it involves complex and interconnected structural and functional processes that may influence health later in life. Magnetic resonance imaging is a powerful tool to investigate equ ...

Nature Portfolio2022

Neutrophil metabolism in the cancer context

Anita Bodac

Neutrophils are critical innate immune cells for the host anti-bacterial defense. Throughout their lifecycle, neutrophils are exposed to different microenvironments and modulate their metabolism to survive and sustain their functions. Although tumor cell m ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2021

Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis

Josefine Catharina Pedersen Tratwal

Over the last decade, bone marrow (BM) adipose tissue (BMAT) has emerged as a distinct adipose depot with unique metabolic properties and effects both in homeostasis and in the progression of disease. We provide a first comprehensive review of existing an ...

EPFL2020

Adaptive damage retention mechanism enables healthier yeast population

Riccardo Dainese

During cytokinesis in budding yeast (Saccharomyces cerevisiae) damaged proteins are distributed asymmetrically between the daughter and the mother cell. Retention of damaged proteins is a crucial mechanism ensuring a healthy daughter cell with full replica ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2019

T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNF alpha Expression and Empower Adoptive Cell Therapy for Solid Tumors

Melody Swartz

Donor-derived allogeneic T cells evoke potent graft versus tumor (GVT) effects likely due to the simultaneous recognition of tumor-specific and host-restricted minor histocompatibility (H) antigens. Here we investigated whether such effects could be reprod ...

Amer Assoc Cancer Research2017