Publications associées à Sex differences in the association of Alzheimer's disease biomarkers and cognition in a multicenter memory clinic study

Publications associées (13)

Structural investigations of brain and skin tissues in Parkinson's and related diseases, using correlative light and electron microscopy

Parkinson's disease (PD), Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) are neurodegenerative disorders collectively termed synucleinopathies, as they all present proteinaceous pathological aggregates of alpha-synuclein (aSyn) in the br ...

EPFL2025

Cerebrospinal ceramides and cognition as a function of striatal asymmetry in early stage of Parkinson's disease

Alexandre Cionca

Background Parkinson's disease (PD) is characterized by heterogeneous clinical phenotypes that may be influenced by the asymmetry of striatal denervation. The alpha-Synuclein Origin site and Connectome (SOC) model proposes that different disease onset patt ...

SAGE PUBLICATIONS INC2025

Compound Admittance Matrix Estimation of Three-phase Untransposed Power Distribution Grids using Synchrophasor Measurements

Mario Paolone, Jean-Yves Le Boudec, Fabrizio Sossan, Rahul Kumar Gupta

The paper considers the problem of estimating the parameters of the compound admittance matrix of three-phase untransposed low-and medium-voltage electrical distribution networks using synchrophasor measurements from phasor measurement units (PMUs). The wo ...

2021

Impact of quantum-chemical metrics on the machine learning prediction of electron density

Anne-Clémence Corminboeuf, Alberto Fabrizio, Ksenia Briling

Machine learning (ML) algorithms have undergone an explosive development impacting every aspect of computational chemistry. To obtain reliable predictions, one needs to maintain a proper balance between the black-box nature of ML frameworks and the physics ...

AMER INST PHYSICS2021

Reverse engineering Lewy bodies: how far have we come and how far can we go?

Hilal Lashuel, Somanath Jagannath, Mohamed Bilal Fares

Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important pathological hallmark of Parkinson disease and several other neurodegenerative diseases. Increasing evidence suggests that the aggregation of α-syn has a central ...

2021

Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies

Andrea Pfeifer

The compound screening was initiated with a direct staining assay to identify compounds binding to Tau aggregates and not Abeta plaques using human brain sections derived from late stage Alzheimer's disease donors. The binding of Tau aggregate selective co ...

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER2020

Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease

Hilal Lashuel, Anne-Laure Mahul Mellier, Nadine Aït Bouziad

The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of its physiological functions and its aggregation properties, the sequence determinan ...

Nature Publishing Group2017

The effective reference frame in perceptual judgments of motion direction

Michael Herzog

The retinotopic projection of stimulus motion depends both on the motion of the stimulus and the movements of the observer. In this study, we aimed to quantify the contributions of endogenous (retinotopic) and exogenous (spatiotopic and motion-based) refer ...

Elsevier2015

Optimization based control for target estimation and tracking via highly observable trajectories

Colin Neil Jones, Andrea Alessandretti

This paper presents a Model Predictive Control (MPC) scheme to solve the target estimation and tracking problem. The objective is to derive a feedback law that drives a follower vehicle to a target vehicle using on-line estimation of the target position an ...

2014

Quantitative Structure-Property Relationships for Thermal Stability and Explosive Properties of Chemicals

Thierry Meyer, Nadia Baati, Annik Nanchen, Francis Stoessel

Handling and storing chemicals in the industrial world require a conscientious hazards assessment and the implementation of appropriate measures to ensure safety for the workers, the company, the environment and the society. Reliable evaluations and predic ...

2013

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism. Here, we demonstrate that inhibition of sirtuin 2 (SIRT2) achieves ...

National Academy of Sciences2010

Statistical analysis of clusters of extreme events

Mária Süveges

The thesis is a contribution to extreme-value statistics, more precisely to the estimation of clustering characteristics of extreme values. One summary measure of the tendency to form groups is the inverse average cluster size. In extreme-value context, th ...

EPFL2009

A New SURE Approach to Image Denoising: Interscale Orthonormal Wavelet Thresholding

Michaël Unser, Thierry Blu, Florian Luisier

This paper introduces a new approach to orthonormal wavelet image denoising. Instead of postulating a statistical model for the wavelet coefficients, we directly parametrize the denoising process as a sum of elementary nonlinear processes with unknown weig ...

Institute of Electrical and Electronics Engineers2007