Dynamics of protein synthesis and degradation through the cell cycle

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The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules of the RNA binding protein Bica ...

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Proteins, the central building blocks of life, play pivotal roles in nearly every biological function. To do so, these macromolecular structures interact with their surrounding environment in complex ways, leading to diverse functional behaviors. The predi ...

The cellular protein levels are determined by protein synthesis and turnover rates. Two processes are involved in the proteome's turnover in proliferating cells: protein degradation and dilution. In theory, maintaining the cellular proteome concentration, ...

State-of-the-art object detection and segmentation methods for microscopy images rely on supervised machine learning, which requires laborious manual annotation of training data. Here we present a self-supervised method based on time arrow prediction pre-t ...

Adult autologous human epidermal stem cells can be extensively expanded ex vivo for cell and gene therapy. Identifying the mechanisms involved in stem cell maintenance and defining culture conditions to maintain stemness is critical, because an inadequate ...

We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the su ...

Centrioles are microtubule-based structures crucial for forming flagella, cilia and centrosomes. Through these roles, centrioles are critical notably for proper cell motility, signalling and division. Recent years have advanced significantly our understand ...

Dynamics of protein synthesis and degradation through the cell cycle

Chattez avec Graph Search

De novo protein design by inversion of the AlphaFold structure prediction network

Centromere structure and function: lessons from Drosophila

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins

Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways

Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

Ricca's factors as mobile proteinaceous effectors of electrical signaling

SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

A Geometric Transformer for Structural Biology: Development and Applications of the Protein Structure Transformer

Coordination of protein synthesis and degradation in mammalian cells

Self-supervised Dense Representation Learning for Live-Cell Microscopy with Time Arrow Prediction

Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures

Protein target highlights in CASP15: Analysis of models by structure providers

Towards understanding centriole elimination