Optical pancreatic beta cell based biosensor, applications and glucose monitoring

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All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...

Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells durin ...

The high conductivity of graphene material (or its derivatives) and its very large surface area enhance the direct electron transfer, improving non-enzymatic electrochemical sensors sensitivity and its other characteristics. The offered large pores facilit ...

An optical device for the in noninvasive determination of the concentration of glucose or another analyte in blood using a combination of Raman spectrometry and PPG. The device includes an optical detector, preferably a CMOS imager including pinned photodi ...

Pancreatic beta-cells secrete insulin to lower blood glucose, following a meal. Maintenance of beta-cell function is essential to preventing type 2 diabetes. In pancreatic beta-cells, mitochondrial matrix calcium is an activating signal for insulin secreti ...

Bioluminescent imaging is a powerful technique that enables imaging in living organisms with high sensitivity, low background signal, low cost and without the need for radioactivity. The emitted photons are produced in the oxidation reaction of luciferin c ...

SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that reached pandemic proportions among the human population within months. The reasons for the spectrum of differences in the severity of the disease across the population, an ...

Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are impl ...

Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulato ...

This paper presents the design of CMOS potentiostats using the g(m)/I-D methodology. We investigate the g(m)/I-D methodology as a systematic framework for optimal potentiostat design in terms of power dissipation, noise and area, the three most important p ...

Hypoglycemia is critical condition during diabetic treatment that involves intensive insulin therapy, and it may impair brain function. We aimed to compare cortical responses of three hypoglycemic phases and the restoration of glycemia to control levels af ...

Introduction: Regulation of endogenous glucose production (EGP) is essential for glucose homeostasis. It includes gluconeogenesis (GNG) from non-carbohydrate substrates and hepatic glycogenolysis. Both these pathways are dysregulated in acute stress, but t ...

After decades of research on non-invasive glucose monitoring, invasive devices based on finger blood sampling are still the predominant reference for diabetic patients for accurately measuring blood glucose levels. Meanwhile, research continues improving p ...

Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2 diabetes, and there is consequently extensive interest in increasing endogenous GLP-1 secretion and L-cell abundance. Here we identify G-protein-coupled bile acid receptor ...

Diabetes is a global epidemic with millions of people dying from it every year. Progress in microelectronics and machine learning has led to a huge number of FDA approvals of devices for continuous monitoring and treatment of diabetes with one product usin ...

Wireless epidermal wearable devices attract interests and expectations as a tool for personalized, low-cost health monitoring technology. The concept of the wireless attachable personal health monitoring devices has been more widely considered by combining ...

We present a novel probabilistic finite element method (FEM) for the solution and uncertainty quantification of elliptic partial differential equations based on random meshes, which we call random mesh FEM (RM-FEM). Our methodology allows to introduce a pr ...

A bio-electronics system that measures cytosolic [Ca2+] in vitro in the INS-1E pancreatic beta-cells using a 430 nm excitation light with the excitation wavelength of the probe being at 435 nm was successfully implemented and tested. We transfected the INS ...

Diabetes impacts the central nervous system predisposing to cognitive decline. While glucose is the main source of energy fueling the adult brain, brain glycogen is necessary for adequate neuronal function, synaptic plasticity and memory. In this study, we ...

Optical pancreatic beta cell based biosensor, applications and glucose monitoring

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Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

Cost Effective Synthesis of Graphene Nanomaterials for Non-Enzymatic Electrochemical Sensors for Glucose: A Comprehensive Review

Non-invasive glucose sensor

Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic beta-cells

A 6-to-8GHz 0.17mW/Qubit Cryo-CMOS Receiver for Multiple Spin Qubit Readout in 40nm CMOS Technology

Development of novel tools for imaging of metabolic fluxes in vivo

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Design of Low-Power Highly Accurate CMOS Potentiostat Using the g(m)/I-D Methodology

Metabolic and perfusion responses to acute hypoglycemia in the rat cortex: A non-invasive magnetic resonance approach

Magnitude of gluconeogenesis and endogenous glucose production: are they predictable in clinical settings?

Very Selective Detection of Low Physiopathological Glucose Levels by Spontaneous Raman Spectroscopy with Univariate Data Analysis

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Optical microsystems for genetically engineered biosensors. Case study: Glucose monitoring

Wearable and Battery-Free Health-Monitoring Devices With Optical Power Transfer

A probabilistic finite element method based on random meshes: A posteriori error estimators and Bayesian inverse problems

Pancreatic beta cell based optical biosensor and system for continuous glucose monitoring

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto‐Kakizaki rats