The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

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Machine translation (MT) systems and language models (LMs) have demonstrated impressive performance in recent years, driven by advances in architecture, algorithms, and the scaling of parameters and training data. Despite the ability of these models to int ...

The Septation Initiation Network (SIN) is a conserved signal transduction network, which is important for cytokinesis in S. pombe. The SIN component Etd1p is required for association of some SIN proteins with the spindle pole body (SPB) during anaphase and ...

The septation initiation network (SIN) is a conserved signal transduction network, which is important for cytokinesis in Schizosaccharomyces pombe. The SIN component Etd1p is required for association of some SIN proteins with the spindle pole body (SPB) du ...

The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...

Two -particle Bose-Einstein momentum correlation functions are studied for charged-hadron pairs in lead -lead collisions at a center -of -mass energy per nucleon pair of .'/sNN = 5.02 TeV. The data sample, containing 4.27 x 109 minimum bias events correspo ...

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...

Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the epigenetic mechanisms underlying human cell diversity has been di ...

Rectified-linear-unit (ReLU) neural networks, which play a prominent role in deep learning, generate continuous and piecewise-linear (CPWL) functions. While they provide a powerful parametric representation, the mapping between the parameter and function s ...

Protein kinases of the dystonia myotonica protein kinase (DMPK) family are critical regulators of actomyosin contractility in cells. The DMPK kinase MRCK1 is required for the activation of myosin, leading to the develop-ment of cortical tension, apical con ...

The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) is a brain area subject to many theories and debates over its function(s). Even its precise anatomical borders are subject to much controversy. In the past decades, the dmPFC/d ...

In this thesis we consider the problem of estimating the correlation of Hecke eigenvalues of GL2 automorphic forms with a class of functions of algebraic origin defined over finite fields called trace functions. The class of trace functions is vast and inc ...

Polymer brushes have been theoretically described, their behavior under diverse conditions has been modeled, and their preparation via surface-initiated polymerizations (SIPs) has been progressively refined. However, despite three decades of research endea ...

Dense image-based prediction methods have advanced tremendously in recent years. Their remarkable development has been possible due to the ample availability of real-world imagery. While these methods work well on photographs, their abilities do not genera ...

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

The recent developments of deep learning cover a wide variety of tasks such as image classification, text translation, playing go, and folding proteins. All these successful methods depend on a gradient-based learning algorithm to train a model on massive ...

Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...

Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the dev ...

A vehicle's steering is a particular system in that it is exposed to individual subjective reviews based on criteria that are hard to assess quantitatively. Haptic design of such systems is a prime concern that has been at the center of industrial developm ...

Background: Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes from early embryo- genesis to innate ...

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

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From Preprocessing to Evaluation: The Role of External Knowledge in Advancing Language Models and Machine Translation

Primary data for "A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network"

A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

Two-particle Bose-Einstein correlations and their Lévy parameters in PbPb collisions at √sNN=5.02 TeV

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Stable parameterization of continuous and piecewise-linear functions

Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase

Debates on the dorsomedial prefrontal/dorsal anterior cingulate cortex: insights for future research

Algebraic twists of GL(2) automorphic forms

Opportunities, Challenges, and Pitfalls in Making, Characterizing, and Understanding Polymer Brushes

Dense Image-based Predictions for Comics Analysis

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Transformer Models for Vision

Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo

Haptics based collaborative steering control in automated driving environments

Statistical learning quantifies transposable element-mediated cis-regulation