System for micturition control in a mammal with bladder disfunction

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Background: Emerging research increasingly supports that epidural spinal cord electrical stimulation (EES) combined with neurorehabilitation can improve motor recovery in spinal cord injury (SCI) subjects. Patients with lesions involving the medullary cone ...

Urinary incontinence (UI) is prevalent and distressing medical condition affecting millions of patients worldwide. Current treatment options for severe cases often involve surgical intervention, such as the implantation of an artificial urinary sphincter ( ...

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...

Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve a ...

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

Electrical stimulation of the nervous system has emerged as a promising assistive technology in case of many injuries and illnesses across various parts of the nervous system. In particular, the invasive neuromodulation of the peripheral nervous system see ...

Neuroprosthetic devices used for the treatment of lower urinary tract dysfunction, such as incontinence or urinary retention, apply a pre-set continuous, open-loop stimulation paradigm, which can cause voiding dysfunctions due to neural adaptation. In the ...

Over the past two decades, epidural electrical stimulation (EES) has transitioned from a treatment for chronic pain to a promising paradigm for ameliorating deficits associated with neurological disorders like spinal cord injury (SCI) and Parkinson's Disea ...

Low urinary tract dysfunctions and symptoms (LUTS) and Urinary incontinence (UI) in particular is a medical condition that affects millions of people worldwide. One of the most promising long term treatments for this condition is the use of an artificial u ...

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

Spinal Cord Injury (SCI) affects almost 500,000 people every year, causing complete paralysis of both legs in severe cases, with no current treatment perspective. However, new neuroengineering technologies, such as the Brain Spine Interface (BSI), have eme ...

Spinal cord injury (SCI) interrupts axonal connections between the brain and the spinal cord, and is characterized by a spectrum of sensorimotor and autonomic impairments. While spontaneous recovery is limited, recent studies have shown that functional imp ...

SiliFish is an open-source desktop application tomodel and study zebrafish swimming. Here, we explain how to define the general parameters of the model, define cell populations, place them within the spinal cord, and define their projections. We explain ho ...

Spinal-cord injury interrupts communication between the brain and spinal cord, leading to paralysis. An implant that decodes the brain signals that control movements and drives electrical stimulation of the spinal cord re-establishes this communication, en ...

Quadruped animal locomotion emerges from the interactions between the spinal central pattern generator (CPG), sensory feedback, and supraspinal drive signals from the brain. Computational models of CPGs have been widely used for investigating the spinal co ...

Treatment-resistant depression is a severe form of major depressive disorder and deep brain stimulation is currently an investigational treatment. The stimulation's therapeutic effect may be explained through the functional and structural connectivities be ...

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

Spinal Cord Injury (SCI) results in damage to neural circuitry connecting the brain to the periphery. Consequently, sensory and motor function is lost, to varying degree, depending on the site and severity of the lesion. More than half of spinal cord injur ...

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

System for micturition control in a mammal with bladder disfunction

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Epidural electrical stimulation facilitates motor recovery in spinal cord injury involving the conus medullaris: A case study

An artificial urinary sphincter based on dielectric elastomer technology

System for control of spasticity

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

Multimodal transcriptomic atlases of mouse spinal cord injury

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Decoding bladder state from pudendal intraneural signals in pigs

Closed-Loop Control of Epidural Electrical Stimulation in Patients with Spinal Cord Injury and Parkinson's Disease

Mechanical Characterisation of Porcine Urethra: Non Linear Constitutive Models and Experimental Approach

Walking naturally after spinal cord injury using a brain-spine interface

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Brain-controlled spinal cord stimulation to restore mobility after spinal cord injury

Targeted regeneration of spinal cord neurons across a complete injury restores walking

SiliFish: A desktop application to model swimming behavior in developing zebrafish (Danio rerio)

A digital bridge between brain and spinal cord restores walking after paralysis

Puppeteer and Marionette: Learning Anticipatory Quadrupedal Locomotion Based on Interactions of a Central Pattern Generator and Supraspinal Drive

Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series

Natural and targeted circuit reorganization after spinal cord injury

Sensor-based control strategies for integration of epidural electrical stimulation in rehabilitation after spinal cord injury

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models