Publications associées à Following spatial A beta aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics

Publications associées (28)

Combining Liquid Chromatography and Cryogenic IR Spectroscopy in Real Time for the Analysis of Oligosaccharides

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Ali H Abikhodr

While the combination of liquid chromatography (LC) and mass spectrometry (MS) serves as a robust approach for oligosaccharide analysis, it has difficulty distinguishing the smallest differences between isomers. The integration of infrared (IR) spectroscop ...

Amer Chemical Soc2024

Orchestrating chromosome conformation capture analysis with Bioconductor

Cyril Matthey-Doret

Genome-wide chromatin conformation capture assays provide formidable insights into the spatial organization of genomes. However, due to the complexity of the data structure, their integration in multi-omics workflows remains challenging. We present data st ...

Nature Research2024

Data-driven statistical optimization of a groundwater monitoring network

Andrea Rinaldo

We propose a comparative study of three different methods aimed at optimizing existing groundwater monitoring networks. Monitoring piezometric heads in subsurface porous formations is crucial at regional scales to properly characterize the relevant subsurf ...

Elsevier2024

Seeking the new, learning from the unexpected: Computational models of surprise and novelty in the brain

Alireza Modirshanechi

Human babies have a natural desire to interact with new toys and objects, through which they learn how the world around them works, e.g., that glass shatters when dropped, but a rubber ball does not. When their predictions are proven incorrect, such as whe ...

EPFL2024

A Snapshot on the Buildup of the Stable Water Isotopic Signal in the Upper Snowpack at EastGRIP on the Greenland Ice Sheet

Sonja Wahl

The stable water isotopic composition in firn and ice cores provides valuable information on past climatic conditions. Because of uneven accumulation and post-depositional modifications on local spatial scales up to hundreds of meters, time series derived ...

AMER GEOPHYSICAL UNION2023

Molecular reconstruction and simulation of the Neuron-Glia-Vasculature system

Polina Shichkova

The outstanding information processing capacity of the brain relies on numerous molecular mechanisms. It is an extremely energy-expensive function, which involves specialization and collaboration of different cell types. A common framework to study the com ...

EPFL2023

E-Scan: Consuming Contextual Data with Model Plugins

Anastasia Ailamaki, Viktor Sanca

Extracting value and insights from increasingly heterogeneous data sources involves multiple systems combining and consuming the data. With multi-modal and context-rich data such as strings, text, videos, or images, the problem of standardizing the data mo ...

2023

Deconstructing and Reconstructing the Complexity of Tau pathology

Galina Limorenko

This thesis consists of four Chapters unified by a singular theme â how do we develop disease models that faithfully reproduce the pathology seen in patients suffering from neurodegenerative disorders associated with the Tau protein, such as Alzheimerâ ...

EPFL2023

Isotope Ratio - Discharge Relationships of Solutes Derived From Weathering Reactions

Paolo Benettin

To date, the vast majority of studies seeking to link discharge to solute concentrations have been based on representations of fluid age distributions in watersheds that are time-invariant. As increasingly detailed spatial and temporal datasets become avai ...

Amer Journal Science2023

Tissue clearing applications in memory engram research

Johannes Gräff

A memory engram is thought to be the physical substrate of the memory trace within the brain, which is generally depicted as a neuronal ensemble activated by learning to fire together during encoding and retrieval. It has been postulated that engram cell e ...

FRONTIERS MEDIA SA2023

Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

Maria del Carmen Sandi Perez

The brain and behavior are under energetic constraints, limited by mitochondrial energy transformation capacity. However, the mitochondria-behavior relationship has not been systematically studied at a brain-wide scale. Here we examined the association bet ...

Nature Research2023

Brain dynamics uncovered using a machine-learning algorithm

Mackenzie Mathis

CEBRA is a machine-learning method that can be used to compress time series in a way that reveals otherwise hidden structures in the variability of the data. It excels at processing behavioural and neural data recorded simultaneously, and it can decode act ...

NATURE PORTFOLIO2023

Rapid grain boundary diffusion in foraminifera tests biases paleotemperature records

Anders Meibom, Jaroslaw Hubert Stolarski, Lukas Baumgartner, Arthur Adams, Deyanira Graciela Cisneros Lazaro, Jinming Guo

The paleoseawater temperature record from the oxygen isotope compositions of fossil foraminifera tests may be biased by up to about 1 degrees C due to grain-boundary diffusion alone, according to isotope exchange experiments on foraminifera tests. The oxyg ...

2023

A parcellation scheme of mouse isocortex based on reversals in connectivity gradients

Michael Reimann

The brain is composed of several anatomically clearly separated structures. This parcellation is often extended into the isocortex, based on anatomical, physiological or functional differences. Here, we derive a parcellation scheme based purely on the spat ...

2023

Dataset for "Elastocapillary menisci mediate interaction of neighboring structures at the surface of a compliant solid"

John Martin Kolinski, Lebohang Molefe

This dataset supports the publication 'Elastocapillary menisci mediate interaction of neighboring structures at the surface of a compliant solid' by Lebo Molefe and John M. Kolinski, Physical Review E, (2023). The data are surface profiles of textured surf ...

Zenodo2023

Assessing sublimation during snow transport and sublimation effects on the isotopic composition of water vapor

Armin Sigmund

Sublimation influences the water storage in snow covers and glaciers, which is important for water use and projections of the sea level rise. Yet, it is challenging to quantify sublimation for large areas or in conditions of snow transport. In-situ measure ...

EPFL2023

Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions

Yanan Niu

Atherosclerosis is a complex disease altering vasculature morphology, and subsequently flow, with progressive plaque formation, mural disruption, and lumen occlusion. Determination of clinically-relevant plaque components-particularly calcium, lipid, and f ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Computational Concepts for Reconstructing and Simulating Brain Tissue

Felix Schürmann, Srikanth Ramaswamy, Jean-Denis Georges Emile Courcol

It has previously been shown that it is possible to derive a new class of biophysically detailed brain tissue models when one computationally analyzes and exploits the interdependencies or the multi-modal and multi-scale organization of the brain. These re ...

Springer2022

Simulating the progression of brain structural alterations in Parkinson's disease

Chang-Hyun Park

Considering brain structural alterations as neurodegenerative consequences of Parkinson's disease (PD), we sought to infer the progression of PD via the ordering of brain structural alterations from cross-sectional MRI observations. Having measured cortica ...

NATURE PORTFOLIO2022

Persistence of the isotopic signature of pentavalent uranium in magnetite

Rizlan Bernier-Latmani, Barbora Bártová, Zezhen Pan

Uranium isotopic signatures can be harnessed to monitor the reductive remediation of subsurface contamination or to reconstruct paleo-redox environments. However, the mechanistic underpinnings of the isotope fractionation associated with U reduction remain ...

2022