Publications associées à Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Publications associées (29)

"Heat of the Moment: The Overlooked Key to Cartilage Engineering''

Dominique Pioletti, Theofanis Stampoultzis

Articular cartilage's limited regenerative capacity is compounded by the overlooked thermomechanical factors critical to its function. Recent studies emphasize the importance of cartilage self-heating, arising predominantly from energy dissipation under ph ...

AMER CHEMICAL SOC2025

Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature

Theofanis Stampoultzis

Chondrocytes within articular cartilage possess the capacity to perceive and react to signals generated by the typical load-bearing actions of daily life, such as walking or running. Articular cartilage is predominantly oriented toward compression-based fu ...

EPFL2024

Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

Yanheng Guo

Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...

EPFL2024

Shaped Laser Pulses for Microsecond Time-Resolved Cryo-EM: Outrunning Crystallization during Flash Melting

Marcel Drabbels, Ulrich Lorenz, Constantin Richard Krüger, Nathan Junior Mowry

Water vitrifies if cooled at rates above 3 × 105 K/s. In contrast, when the resulting amorphous ice is flash heated, crystallization occurs even at a more than 10 times higher heating rate, as we have recently shown. This may present an issue for microseco ...

2024

Flash Melting Amorphous Ice

Marcel Drabbels, Ulrich Lorenz, Gabriele Bongiovanni, Constantin Richard Krüger, Nathan Junior Mowry

Water can be vitrified if it is cooled at high rates, which makes it possible to outrun crystallization in so-called no man’s land, a range of deeply supercooled temperatures where water crystallizes rapidly. Here, we study the reverse process in pure wate ...

2024

Surgical approaches to the capitellum: a comparative anatomic study

Alexandre Terrier, Patrick Goetti, Frédéric Vauclair

Background: Osteochondritis dissecans (OCD) of the humeral capitellum is an important cause of elbow disability in young athletes. Large and unstable lesions sometimes require joint reconstruction with osteochondral autograft. Several approaches have been ...

Mosby-Elsevier2024

Innovative thermophysical characterization of an ATF composite cladding: the case of silicon carbide

Andrea Cavaliere

Nuclear power is a powerful technology that plays an important role in the fight against climate change, and research is continuously engaged in studies that could further improve its safety. After the Fukushima accident, Accident Tolerant Fuels research h ...

EPFL2024

Renewable Energy Integration and Waste Heat Recovery for the Production of Sustainable Jet Fuel and Decarbonization of Industrial Heating Applications

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos

The process synthesis and optimization methods used in this work include simulation of biomass gasification, hydrogen and synthetic natural gas production, and jet fuel production via a Fisher Tropsch unit. An energy integration approach, carried out by th ...

American Institute of Chemical Engineering2023

Transparent structured conductive coating for applications in smart windows

Jérémy Jacques Antonin Fleury

Solar radiation reaching the surface of the earth for a period of one hour contains more energy than that consumed by mankind over an entire year. Some of this solar energy is already collected by photovoltaic cells to cover the electricity needs of buildi ...

EPFL2023

Nanoscale thermal control of a single living cell enabled by diamond heater-thermometer

Aleksandra Radenovic, Evgenii Glushkov

We report a new approach to controllable thermal stimulation of a single living cell and its compartments. The technique is based on the use of a single polycrystalline diamond particle containing silicon-vacancy (SiV) color centers. Due to the presence of ...

Nature Portfolio2023

DeepValve: Development and experimental testing of a Reinforcement Learning control framework for occupant-centric heating in offices

Dolaana Khovalyg, Amirreza Heidari

Space heating controls in offices usually follow static schedules detached from actual occupancy, which results in energy waste by unnecessarily heating vacant offices. The uniqueness of stochastic occupancy profile and thermal response time of each office ...

2023

Light-Driven Thermo-Optical Effects in Nanoresonator Arrays

Alfredo Angelo Luigi Naef, Giulia Tagliabue, Theodoros Tsoulos, Ershad Mohammadi

Thermonanophotonics, that is the study of photothermal effects in optical nanoantennas, has recently attracted growing interest. In particular, going beyond thermoplasmonic designs, thermo-optical modulation of dielectric nanoantennas opens new opportuniti ...

WILEY-V C H VERLAG GMBH2023

Morphological assessment of cartilage and osteoarthritis in clinical practice and research: Intermediate-weighted fat-suppressed sequences and beyond

Tom Hilbert

Magnetic resonance imaging (MRI) is widely regarded as the primary modality for the morphological assessment of cartilage and all other joint tissues involved in osteoarthritis. 2D fast spin echo fat-suppressed intermediate-weighted (FSE FS IW) sequences w ...

SPRINGER2023

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Pernille Yde Rainer

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated como ...

EPFL2023

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Dominique Pioletti, Peyman Karami, Yanheng Guo, Theofanis Stampoultzis

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

ELSEVIER SCI LTD2023

Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain

Olivier Didier Christian Rizzo, Stéphanie Lacour, John Martin Kolinski, Outman Akouissi, Michael Shur

The brain is an ultra-soft viscoelastic matrix. Sub-kPa hydrogels match the brain's mechanical properties but are challenging to manipulate in an implantable format. We propose a simple fabrication and processing sequence, consisting of de-hydration, patte ...

2023

Heat pumping and renewable energy integration for decarbonizing brewery industry and district heating

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos

The energy integration of brewery plants and urban agglomerations has many benefits in terms of rational energy use and reduced environmental impact, especially during scenarios of uncertain supply chain and volatile market prices. In fact, the diversifica ...

Elsevier2023

High power mm-wave loss measurements of ITER ex-vessel waveguide components at the FALCON test facility at the Swiss Plasma Center

Timothy Goodman, René Chavan, Avelino Mas Sanchez, Anastasia Xydou, Cinta Lucia Marraco Borderas, Humberto Torreblanca Quiroz

Many future fusion devices will rely heavily, if not solely, on electron cyclotron (EC) heating subsystems to provide bulk heating, instability control (neoclassical tearing mode (NTM) stabilization), and thermal instability control. Efficient use of the i ...

E D P SCIENCES2023

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

Maria Brbic

Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We c ...

American Association for the Advancement of Science2023

Self-heating analysis of monolithically integrated hybrid III-V/Si PIN diode

Kirsten Emilie Moselund

Self-heating is a crucial effect in integrated nanophotonic devices regarding their power consumption. In this work, we employ coupled 3D thermo-electrical simulations to gain insight into the thermal behavior related to traps in a monolithic InP-InGaAs-In ...

SPIE-INT SOC OPTICAL ENGINEERING2022