Publications associées à KP1019, a new redox-active anticancer agent - preclinical development and results of a clinical phase I study in tumor patients

Publications associées (25)

Multiscale Porosity Microfluidics to Study Bacterial Transport in Heterogeneous Chemical Landscapes

Microfluidic models are proving to be powerful systems to study fundamental processes in porous media, due to their ability to replicate topologically complex environments while allowing detailed, quantitative observations at the pore scale. Yet, while por ...

Wiley2024

Appropriations and Uses of Travel Time

Ludy Juliana González Villamizar

Time has always been a central factor in understanding the challenges of daily mobility. For a long time, and still today, methods of economic evaluation of transport projects have monetized time savings so that they can be included in the cost–benefit ana ...

ISTE Wiley2023

Pathways to enhance electrochemical CO2 reduction identified through direct pore-level modeling

Sophia Haussener, Etienne Boutin, Shuo Liu, Evan Fair Johnson

Electrochemical conversion of CO2 to fuels and valuable products is one pathway to reduce CO2 emissions. Electrolyzers using gas diffusion electrodes (GDEs) show much higher current densities than aqueous phase electrolyzers, yet models for multi-physical ...

2023

A spectroscopic inference and SOLPS-ITER comparison of flux-resolved edge plasma parameters in detachment experiments on TCV

Basil Duval, Holger Reimerdes, Christian Gabriel Theiler, Kevin Henricus Annemarie Verhaegh, Mirko Wensing, Artur Perek

This work presents the use of a collisional-radiative model to infer plasma parameters from 2D emissivities of several deuterium Balmer lines. The emissivities were obtained by MANTIS, an absolutely calibrated, ten-camera imaging polychromator with

IOP Publishing Ltd2022

Microfluidic-Based Study on the Activation and Evolution of Calcite Bio-Mineralization for Geotechnical Applications

Lyesse Laloui, Dimitrios Terzis, Filippo Miele, Ariadni Elmaloglou

The field of geotechnics is moving fast towards benefiting from new methods and tools to improve the understanding of couplings among complex transport, chemical and biological phenomena. Calcite bio-mineralization, result of bio-grouting, stands out as su ...

ASCE2020

Origin and role of the cerebrospinal fluid bidirectional flow in the central canal

François Gallaire, Ludovic Pierre Gustave Keiser

Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord of 30 hpf zebrafish embryos and it ...

2020

Density effects on nanoparticle transport in the hyporheic zone

Qihao Jiang, David Andrew Barry, Ho Ling Li

A carbon solution composed of nanoparticles was used in experiments designed to explore nanoparticle transport characteristics within the hyporheic zone of a riverbed. Experiments and numerical simulations demonstrated that nanoparticle transport in the hy ...

2018

Frequent walkers: from healthy individual behaviours to sustainable mobility futures

Derek Pierre Christie

Walking is often taken for granted or considered as an ancillary activity. Little is known about the distribution of walking in contemporary populations, and even less about the few people who walk for an hour or more in public space on most days of the we ...

EPFL2018

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Melody Swartz, Marco Pisano, Esra Güç, Valentina Triacca

Rationale: The transport of interstitial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering antigens and soluble factors to the lymph node for immune surveillance. Transendothelial transport across ...

Lippincott Williams & Wilkins2017

Towards self-consistent plasma modelisation in presence of Neoclassical Tearing Mode and sawteeth: effects on transport coefficients

Olivier Sauter

The neoclassical tearing modes (NTM) increase the effective heat and particle radial transport inside the plasma, leading to a flattening of the electron and ion temperature and density profiles at a given location depending on the safety factor q ration ...

2017

Accessible triple-phase boundary length: A performance metric to account for transport pathways in heterogeneous electrochemical materials

Jan Van Herle, Marco Cantoni, Arata Nakajo

The performance of materials for electrochemical energy conversion and storage depends upon the number of electrocatalytic sites available for reaction and their accessibility by the transport of reactants and products. For solid oxide fuel/electrolysis ce ...

Elsevier Science Bv2016

Protons and Hydroxide Ions in Aqueous Systems

Sylvie Roke

Understanding the structure and dynamics of water's constituent ions, proton and hydroxide, has been a subject of numerous experimental and theoretical studies over the last century. Besides their obvious importance in acid-base chemistry, these ions play ...

American Chemical Society2016

Thermal gate, a new tool for ionic transport control inside nanochannels

Philippe Renaud, Arnaud Bertsch, Mojtaba Taghipoor

Transport of ionic species solvated in electrolytes depends on temperature. This dependence is much stronger in nanofluidics than large scale since the surface charge also varies with temperature. In this work, we introduce a new tool for the modulation of ...

IEEE2015

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model

Lionel André Maurizi

BACKGROUND: Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials in consumer and medical products. Several epidemiologic and invitro studies have shown that nan ...

2015

Iron regulatory proteins and their role in controlling iron metabolism

Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which control the expression of proteins involved in iron uptake, release and storage. Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 and ...

Royal Soc Chemistry2015

Theory of percolation and tunneling regimes in nanogranular metal films

Claudio Grimaldi

Nanogranular metal composites, consisting of immiscible metallic and insulating phases deposited on a substrate, are characterized by two distinct electronic transport regimes depending on the relative amount of the metallic phase. At sufficiently large me ...

Amer Physical Soc2014

Reaction kinetics of dolomite and portlandite

Karen Scrivener, Xinyu Zhang

The reactions of dolomite with portlandite have been studied at well-spaced temperatures between 20 degrees C and 85 degrees C using XRD Rietveld, TG and SEM methods. The results show quantitatively the faster rates of reaction at higher temperature. Isoth ...

Pergamon-Elsevier Science Ltd2014

A study of the spatio-temporal behaviour of bed load transport rate fluctuations

Joris Heyman

This thesis addresses the problem of a statistical description of the transport of sediment as bed load. It highlights the role of fluctuations arising during the transport process, and their impact on macroscopic averages. The results presented here are b ...

EPFL2014

Chloride circulation in a lowland catchment and the formulation of transport by travel time distributions

Andrea Rinaldo, Paolo Benettin

Travel times are fundamental catchment descriptors that blend key information about storage, geochemistry, flow pathways and sources of water into a coherent mathematical framework. Here we analyze travel time distributions (TTDs) (and related attributes) ...

Amer Geophysical Union2013

Catchment-scale herbicides transport: Theory and application

Andrea Rinaldo, Enrico Bertuzzo

This paper proposes and tests a model which couples the description of hydrologic flow and transport of herbicides at catchment scales. The model accounts for streamflow components' age to characterize short and long term fluctuations of herbicide flux con ...

Elsevier Sci Ltd2013