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Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

Publications associées (28)

A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity

Srikanth Ramaswamy, Vignayanandam Ravindernath Muddapu

Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). Although many mechanisms have been suggested, a decisive root cause of this cell loss is ...

2019

Classification of degenerative parkinsonism subtypes by support-vector-machine analysis and striatal I-123-FP-CIT indices

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti

ObjectivesTo provide an automated classification method for degenerative parkinsonian syndromes (PS) based on semiquantitative I-123-FP-CIT SPECT striatal indices and support-vector-machine (SVM) analysis.Methods(123)I-FP-CIT SPECT was performed at a singl ...

Springer2019

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Ursula Röthlisberger, Paolo Carloni, Siri Camee van Keulen, Daniele Narzi

Author summary Adenylyl cyclases (ACs) are enzymes that can translate extracellular signals into the intracellular molecule cAMP, which is thus a 2nd messenger of extracellular events. The brain expresses nine membrane-bound AC variants, and AC5 is the dom ...

2019

Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus

Philippe Renaud, André Mercanzini, Thuy Anh Khoa Nguyen

Objective Segmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the volume ...

PUBLIC LIBRARY SCIENCE2019

The dopaminergic VTA - basal amygdala projection contributes to signal aversive state in fear memory

Wei Tang

Dopamine released from midbrain neurons is an important neuromodulatory signal during associative learning in many forebrain circuits. One model of associative learning is auditory cued fear learning, during which an innocuous sensory percept like a tone ( ...

EPFL2018

Two-photon calcium imaging of neocortical projection neurons in whisker somatosensory cortex during goal-directed sensorimotor learning

Dimitra Angeliki Vavladeli

Excitatory projection neurons of the neocortex are thought to play important roles in perceptual and cognitive functions of the brain by directly connecting diverse cortical and subcortical areas. However, many aspects of the anatomical and functional orga ...

EPFL2018

Layer, cell-type and pathway-specific thalamocortical input to mouse somatosensory cortex

Berat Semihcan Sermet

In the mouse whisker system, sensory information is relayed to the whisker somatosensory cortex by two major thalamic nuclei, the ventral posterior medial nucleus (VPM) and the posterior medial nucleus (POM). While the cortical axonal innervation pattern o ...

EPFL2018

Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism

Tomislav Milekovic, Grégoire Courtine, Eduardo Martin Moraud, Shiqi Sun

Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...

2018