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Publication

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

Tobias Kober, Bénédicte Marie Maréchal, Ricardo Alberto Corredor Jerez
2020
Journal Articles

Résumé

Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease progression. The aim of our study was to assess serum glial fibrillary acid protein (s-GFAP) and neurofilament light chain (s-NfL) in a cohort of 129 multiple sclerosis (MS) patients. Eighteen primary progressive multiple sclerosis (PPMS) and 111 relapsing remitting MS (RRMS) were included. We showed that these 2 biomarkers were significantly correlated with each other (R=0.72, p

Source officielle

https://infoscience.epfl.ch/entities/publication/882327aa-28ae-4917-8340-ed301ed66b60

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Tobias Kober, Bénédicte Marie Maréchal, Ricardo Alberto Corredor Jerez
2020
Journal Articles

Résumé

Source officielle

https://infoscience.epfl.ch/entities/publication/882327aa-28ae-4917-8340-ed301ed66b60

À propos de ce résultat

Concepts associés (21)

Sclérose en plaques

La sclérose en plaques (SEP) est une maladie auto-immune touchant le système nerveux central (cerveau, moelle spinale et nerfs optiques). La cause est multifactorielle : prédisposition génétique, certains facteurs environnementaux (qui ne sont pas encore très bien compris à ce jour), origines infectieuses notamment liées au virus EBV, etc.. Ces divers facteurs augmentent le risque de développer la maladie.

Multiple sclerosis signs and symptoms

Multiple sclerosis can cause a variety of symptoms: changes in sensation (hypoesthesia), muscle weakness, abnormal muscle spasms, or difficulty moving; difficulties with coordination and balance; problems in speech (dysarthria) or swallowing (dysphagia), visual problems (nystagmus, optic neuritis, phosphenes or diplopia), fatigue and acute or chronic pain syndromes, bladder and bowel difficulties, cognitive impairment, or emotional symptomatology (mainly major depression).

Biomarker (medicine)

In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state. It may be defined as a "cellular, biochemical or molecular alteration in cells, tissues or fluids that can be measured and evaluated to indicate normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention." More generally a biomarker is anything that can be used as an indicator of a particular disease state or some other physiological state of an organism.

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Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

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