Systems biology has long been interested in models capturing both metabolism and expression in a cell. We propose here an implementation of the metabolism and expression model formalism (ME-models), which we call ETFL, for Expression and Thermodynamics Flu ...
This thesis develops mathematical programming frameworks to operate electric autonomous vehicles in the context of ride-sharing services. The introduced problem is a novel variant of the Dial-a-Ride Problem (DARP), denoted by the electric Autonomous Dial-a ...
Load-bearing systems (structures) in buildings and infrastructure contribute to a significant share of adverse environmental impacts (EI) because of resource- and energy-intensive fabrication. A currently overlooked circular economy strategy to reduce EI i ...
An important share of building environmental impacts is embodied in load-bearing structures because of their large material mass and energy-intensive fabrication process. To reduce substantially material consumption and waste caused by the construction ind ...
Computational studies of metabolism aim to systematically analyze the metabolic behaviour of biological systems in different conditions. Genome-scale metabolic network models (GEMs) capture the connection between elements of the network by applying stoichi ...
This paper presents optimization methods to design frame structures from a stock of existing elements. These methods are relevant when reusing structural elements over multiple service lives. Reuse has the potential to reduce the environmental impact of bu ...
