Polymeric carriers for therapeutic agents : drug and gene delivery systems by reversible addition-fragmentation transfer (RAFT) polymerization

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The wetting dynamics of molten thermoplastic polymers, which are known to influence the force balance of the triple line, are not understood properly despite their importance in many industrial processes. In particular, the influence of the molecular weigh ...

Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...

Adult autologous human epidermal stem cells can be extensively expanded ex vivo for cell and gene therapy. Identifying the mechanisms involved in stem cell maintenance and defining culture conditions to maintain stemness is critical, because an inadequate ...

Multicellular patterning of stem-cell-derived tissue models is commonly achieved via self-organizing activities triggered by exogenous morphogenetic stimuli. However, such tissue models are prone to stochastic behavior, limiting the reproducibility of cell ...

The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research to be accurate, meaning-ful, and durable, standards that ensure reproducibility and ...

This study assesses the influence during interfacial polymerization on polyamide thin film composite (TFC) morphology and performance of varying monomer concentrations and organic phases with widely varying physico-chemical characteristics (interfacial ten ...

The current reliance on limited petrochemical resources and the resulting ecological outcomes have made the exploration of alternative chemical and energy feedstocks invaluable. As such, the development of sustainable processes with a less harmful total en ...

Biomimetic retinas with a wide field of view and high resolution are in demand for neuroprosthetics and robot vision. Conventional neural prostheses are manufactured outside the application area and implanted as a complete device using invasive surgery. He ...

TAR DNA-binding protein with 43 kD (TDP-43) is a partially disordered protein that misfolds and accumulates in the brains of patients affected by several neurodegenerative diseases. TDP-43 oligomers have been reported to form due to aberrant misfolding or ...

Bioaccumulation is defined as the enrichment of a compound in an organism relative to the surrounding water or its food, and is an important endpoint in chemical risk assessment. Under laboratory conditions, bioaccumulation is measured as bioconcentration ...

CAR-T cell therapy has shown remarkable success in treating hematopoietic malignancies, but its efficacy in solid tumors is limited by T cell dysfunction, including exhaustion and senescence. In this study, we designed metabolically armored CAR-T cells to ...

Gene therapy offers the possibility to treat or even cure diseases originating from genetic defects by introducing a therapeutic gene in target cells or correcting the initial defective gene. Amongst different options, non-viral vectors rely on the deliver ...

Polymeric carriers for therapeutic agents : drug and gene delivery systems by reversible addition-fragmentation transfer (RAFT) polymerization

Chattez avec Graph Search

Influence of the molecular weight and physical properties of a thermoplastic polymer on its dynamic wetting behavior

Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures

Programming of Multicellular Patterning with Mechano-Chemically Microstructured Cell Niches

ISSCR standards for the use of human stem cells in basic research

MPD and TMC supply as parameters to describe synthesis-morphology-performance relationships of polyamide thin film composite membranes

Separable Brønsted acidic imidazolium salts for polysaccharide hydrolysis in water

Colloidal self-assembly of soft neural interfaces from injectable photovoltaic microdevices

Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro

The Bioaccumulation of Ionizable Organic Compounds in Fish Cell Lines

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Engineering of chitosan-based derivatives for non-viral gene delivery