Publications associées à ER+ breast cancer in 3D scaffold ex vivo for transcriptomics-based functional drug screening and personalized medicine

Publications associées (9)

Abstract B037: AI-powered virtual tissues from spatial proteomics for clinical diagnostics and biomedical discovery

Eeshaan Jain, Johann Clemens Werner Wenckstern, Charlotte Cäcilie Gertrud Bunne

Spatial proteomics technologies have transformed our understanding of complex tissue architectures by enabling simultaneous analysis of multiple molecular markers and their spatial organization. The high dimensionality of these data, varying marker combina ...

American Association for Cancer Research (AACR)2025

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

Mathieu Girardin

Chimeric antigen receptors (CARs) are synthetic, transmembrane proteins that trigger immune cell signaling following their engagement. They have been first utilized in T cells and later in natural killer (NK) cells to redirect their cytotoxicity toward a s ...

EPFL2023

Prioritization of cell types responsive to biological perturbations in single-cell data with Augur

Grégoire Courtine, Jordan Squair, Matthieu Pierre Gautier, Michael Alexander Skinnider

Advances in single-cell genomics now enable large-scale comparisons of cell states across two or more experimental conditions. Numerous statistical tools are available to identify individual genes, proteins or chromatin regions that differ between conditio ...

NATURE RESEARCH2021

Tweaking DNA of myeloid cells curbs cancer spread

Michele De Palma, Ali Ghasemi

Blood cells called myeloid cells can facilitate metastasis - the spread of a tumour to distant organs. Taming these cells with drugs that alter the chemical structure of their DNA limits metastasis in mice. ...

NATURE PUBLISHING GROUP2020

The G protein coupled receptor CXCR4 designed by the QTY code becomes more hydrophilic and retains cell signaling activity

Horst Arthur Vogel, Horst Pick

G protein-coupled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging. They are involved in a wide range of diseases, and are among the most important targets of medicinal drugs. Tools that facilitate GPCR studi ...

NATURE RESEARCH2020

Thermal Responsive Silk Composite Membrane for Magnetic Field Triggered Controllable Drug Delivery

Ya Wang

Drug delivery implant which provides localized and controlled drug release is beneficial for the therapies of chronic diseases and tumors. This dissertation aims to develop thermal responsive composite membranes that can be utilized as smart drug release i ...

EPFL2020

Monitoring Tuberculosis Drug Activity in Live Animals by Using Near-Infrared Fluorescence Imaging

Stewart Cole, Raphael Christopher Sommer

Worldwide, tuberculosis (TB) is the leading cause of death due to infection with a single pathogenic agent, Mycobacterium tuberculosis. In the absence of an effective vaccine, new, more powerful antibiotics are required to halt the growing spread of multid ...

AMER SOC MICROBIOLOGY2019

Interference of silver nanoparticles with essential metal homeostasis in a novel enterohepatic fish in vitro system

Kristin Schirmer

Silver nanoparticle toxicity has been extensively studied in several vertebrate cells. Its correlation with cellular essential metal homeostasis, however, has largely been overlooked. In this study, we used a novel in vitro model of a fish enterohepatic sy ...

ROYAL SOC CHEMISTRY2019

Metabolomics reveals tepotinib‐related mitochondrial dysfunction in MET activating mutations‐driven models

Katarzyna Pierzchala

Genetic aberrations in the hepatocyte growth factor receptor tyrosine kinase MET induce oncogenic addiction in various types of human cancers, advocating MET as a viable anticancer target. Here, we report that MET signaling plays an important role in confe ...

2019