Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)

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Publications associées (31)

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Ioanna Keklikoglou, Nadine Fournier, Sina Nassiri, Etienne Meylan, Michele De Palma, Ece Kadioglu, Chiara Cianciaruso, Bruno Torchia, Gael Luis Boivin, Alan Nicolas Thierry Guichard, Amaia Martinez Usatorre

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of nonsmall cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic d ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation

Sandrine Gerber, Céline Marie Anne Journot, Laura Camille Louise Nicolle

There is an increasing interest in cationic polymers as important constituents of non-viral gene delivery vectors. In the present study, we developed a versatile synthetic route for the production of covalent polymeric conjugates consisting of water-solubl ...

2021

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot, Maiia Bragina, Augusto Martins Lima

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...

ELSEVIER SCI LTD2021

Thermal Stress Interacts With Surgeonfish Feces to Increase Coral Susceptibility to Dysbiosis and Reduce Tissue Regeneration

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Dysbiosis of coral microbiomes results from various biotic and environmental stressors, including interactions with important reef fishes which may act as vectors of opportunistic microbes via deposition of fecal material. Additionally, elevated sea surfac ...

Frontiers Media SA2021

Microstructured Biodegradable Fibers for Advanced Control Delivery

Inès Richard, Dang Tùng Nguyen, Fabien Sorin, Alexis Gérald Page, Shahrzad Shadman Yazdi, Govindan Narayanan Krishnamani, Jurgis Ruza, Andreas Leber

Biodegradable polymers are increasingly employed at the heart of therapeutic devices. Particularly in the form of thin and elongated fibers, they offer an effective strategy for controlled release in a variety of biomedical configurations such as sutures, ...

WILEY-V C H VERLAG GMBH2020

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

Michele De Palma, Nicolo Rigamonti, Daniela Pais Ferreira, Alan Nicolas Thierry Guichard

Cancer immunotherapies are increasingly combined with targeted therapies to improve therapeutic outcomes. We show that combination of agonistic anti-CD40 with antiangiogenic antibodies targeting 2 proangiogenic factors, vascular endothelial growth factor A ...

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Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices

Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Riccardo Rizzo

Three-dimensional (3D) control over the placement of bioactive cues is fundamental to understand cell guidance and develop engineered tissues. Two-photon patterning (2PP) provides such placement at micro- to millimeter scale, but nonspecific interactions b ...

Wiley-V C H Verlag Gmbh2020

Targeting the oncogenic signaling of the transcription factor STAT3 with potent and selective monobody inhibitors

Grégory La Sala

Many targeted cancer therapies fail to improve the overall survival of patients. Limitations involve low drug selectivity and the rapid development of resistance. Moreover, the majority of oncogenic drivers presently remain considered as undruggable as th ...

EPFL2020

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Bernard Schneider, Paola Andrea Solanes Vega

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

2020

Method and system for analysis of organic material by auto-cathodoluminescence

Hans Mattias Larsson, Marcin Stefan Zielinski

Analyzing isolated collagen gel samples of a rat-tail and bovine hide, we demonstrated in situ detection of spectrally deconvoluted auto-cathodoluminescence signatures of specific molecular content with precise spatial localization over a maximum field of ...

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Released Diclofenac Sodium Salt From Chitosan Embedding In A Hydrogel Matrix. A Theoretical And Experimental Study

Maria-Alexandra Paun

Two formulations embedding diclofenac sodium salt into a chitosan hydrogel matrix with different crosslinking degree were prepared by in situ hydrogelation. The formulations were investigated by polarized light microscopy and scanning electron microscopy, ...

UNIV POLITEHNICA BUCHAREST, SCI BULL2020

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