Effect of inoculum size and antibiotics on bacterial traveling bands in a thin microchannel defined by optical adhesive

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The gut-microbiota-brain axis influences neuroinflammation, neural development and behaviour such as sociability, memory and anxiety. To study these traits in vivo, especially during development or disease, it is crucial to analyse them over time and with ...

β-lactamases from Gram-negative bacteria are generally regarded as soluble, periplasmic enzymes. NDMs have been exceptionally characterized as lipoproteins anchored to the outer membrane. A bioinformatics study on all sequenced beta-lactamases was performe ...

This Thesis introduces technologies for particle manipulation in bioanalytics, designed to advance integrative biology leveraging biomarker quantification. Bioanalytical information is essential for uncovering mechanisms and pathways, particularly in nonco ...

Biochemical reaction rates in microfluidic systems are known to be limited by the diffusional transport of reagents, leading often to lowered sensitivity and/or longer detection times in immunoassays. Several methods, including electrically powering electr ...

Type II NADH dehydrogenase (NDH-2) is an essential component of electron transfer in many microbial pathogens but has remained largely unexplored as a potential drug target. Previously, quinolinyl pyrimidines were shown to inhibit Mycobacterium tuberculosi ...

Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outc ...

Microfluidic electrical impedance flow cytometry is now a well-known and established method for single-cell analysis. Given the richness of the information provided by impedance measurements, this non-invasive and label-free approach can be used in a wide ...

Cell trackers are fluorescent chemical tools that facilitate imaging and tracking cells within live organisms. Despite their versatility, these dyes lack specificity, tend to leak outside of the cell, and stain neighboring cells. Here, we report a dual-act ...

Imaging living cells by atomic force microscopy (AFM) promises not only high-resolution topographical data, but additionally, mechanical contrast, both of which are not obtainable with other microscopy techniques. Such imaging is however challenging, as ce ...

Effect of inoculum size and antibiotics on bacterial traveling bands in a thin microchannel defined by optical adhesive

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Assessment of neurobehavioural traits under gnotobiotic conditions: an approach for multiple analyses in the same mouse

OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles

Combining Hydrodynamic and Electrokinetic Forces for Particle Manipulation in Bioanalytical Microsystems

Efficient AC electrothermal flow (ACET) on-chip for enhanced immunoassays

Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2)

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

Positional dependence of particles and cells in microfluidic electrical impedance flow cytometry: origin, challenges and opportunities

Dual-Activatable Cell Tracker for Controlled and Prolonged Single-Cell Labeling

Photothermal Off-Resonance Tapping for Rapid and Gentle Atomic Force Imaging of Live Cells