Publication

Copper-Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols

Publications associées (29)

Manganese-mediated reductive amidation of esters with nitroarenes

Xile Hu, Chi Wai Cheung, Ning Shen, Peng Wang

Amides are ubiquitous molecules in nature and in synthetic chemistry. Here we report a convenient and efficient method to synthesize N-aryl amides via amidation of esters with nitroarenes. In the presence of manganese metal, this amidation proceeded smooth ...

ROYAL SOC CHEMISTRY2019

Cross-Coupling of Alkyl Redox-Active Esters with Benzophenone Imines: Tandem Photoredox and Copper Catalysis

Xile Hu, Jonathan Balon, Runze Mao

Alkyl amines are an important class of organic compounds in medicinal and materials chemistry. Until now very have been very few methods for the synthesis of alkyl amines by metal‐catalyzed cross‐coupling of alkyl electrophiles with nitrogen nucleophiles. ...

Wiley-VCH Verlag GmbH2018

Decarboxylative C(sp3 )−O Cross-Coupling

Xile Hu, Jonathan Balon, Runze Mao

Alkyl aryl ethers are an important class of compounds in medicinal and agricultural chemistry. Catalytic C(sp3)−O cross‐coupling of alkyl electrophiles with phenols is an unexplored disconnection strategy to the synthesis of alkyl aryl ethers, with the pot ...

Wiley-VCH Verlag GmbH2018

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Direct amidation of esters with nitroarenes

Xile Hu, Chi Wai Cheung, Marten Leendert Ploeger

Esters are one of the most common functional groups in natural and synthetic products, and the one-step conversion of the ester group into other functional groups is an attractive strategy in organic synthesis. Direct amidation of esters is particularly ap ...

Nature Publishing Group2017

Elastomers with tunable dielectric and electromechanical properties

Frank Nüesch

Novel electroresponsive silicone elastomers modified with nitrile groups are presented, whose dielectric permittivity (epsilon') is tuned from epsilon' = 4.3 to epsilon' = 17.4. They are prepared in a one-step process starting from a high molecular weight ...

Royal Society of Chemistry2016

Synergistic effect of carboxylic and amine ligands on the synthesis of CdSe nanocrystals

Martinus Gijs, Virendra Kumar Parashar

We demonstrate the drastic improvement in absorbance and photoluminescence (UV-PL) of CdSe nanocrystals (NCs) upon adding both a carboxylic acid and an amine ligand to the cadmium acetate green chemistry source. We combined carboxylate complexes of lauric ...

Royal Soc Chemistry2016

Copper-Catalyzed Cyanomethylation of Allylic Alcohols with Concomitant 1,2-Aryl Migration: Efficient Synthesis of Functionalized Ketones Containing an α-Quaternary Center

Qian Wang, Ala Bunescu, Jieping Zhu

A copper-catalyzed alkylation of allylic alcohols by alkyl nitriles with concomitant 1,2-aryl migration was developed. Formation of the alkyl nitrile radical was followed by its intermolecular addition to alkenes and the migration of a vicinal aryl group w ...

Wiley-Blackwell2015

Synthesis of Functionalized Epoxides by Copper-Catalyzed Alkylative Epoxidation of Allylic Alcohols with Alkyl Nitriles

Qian Wang, Ala Bunescu, Jieping Zhu

A copper-catalyzed oxyalkylation of allylic alcohols using nonactivated alkyl nitriles as reaction partners was developed. A sequence involving generation of an alkyl nitrile radical followed by its addition to a double bond and a copper-mediated formation ...

Amer Chemical Soc2015