Large-scale kinetic metabolic models of Pseudomonas putida KT2440 for consistent design of metabolic engineering strategies

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Strained ring systems such as cyclobutanes offer unique opportunities for synthetic innovation. Its significant ring strain, caused by compressed bond angles, presents synthetic challenges; however, this same strain renders the ring a valuable handle for a ...

Microorganisms are a key component in the chain of life. They are essential for agriculture, produce a large proportion of oxygen, and play a central role in the cycle of elements. Microorganisms are widely used in the production of food and alcoholic beve ...

Despite the growing interest in emotions in engineering education, empirical research on incorporating them into engineering ethics education is limited. Therefore, we designed this experimental study to assess how different methods for integrating compass ...

Being able to work effectively in a team is a vital professional skill but how do students in different disciplines, engineering and hospitality, display their emotions when working together? We investigated their self-reported use of emotional labour stra ...

Growing evidence indicates that transposable elements (TEs) play important roles in evolution by providing genomes with coding and non-coding sequences. Identification of TE-derived functional elements, however, has relied on TE annotations in individual s ...

Microorganisms are essential for life on Earth, performing key roles in numerous biological processes. Their influence extends across a wide spectrum, from human health and ecological balance to advancements in biotechnology and industrial applications. Th ...

Global change exposes ecosystems to changes in the frequency, magnitude, and concomitancy of disturbances, which impact the composition and functioning of these systems. Here, we experimentally evaluate the effects of salinity disturbances and eutrophicati ...

Vibrio cholerae has caused seven cholera pandemics in the past two centuries. The seventh and ongoing pandemic has been particularly severe on the African continent. Here, we report long read-based genome sequences of six V. cholerae strains isolated in th ...

Materials for high -temperature environments are actively being investigated for deployment in aerospace and nuclear applications. This study uses computational approaches to unravel the crystallography and thermodynamics of a promising class of refractory ...

How chronic mutational processes and punctuated bursts of DNA damage drive evolution of the cancer genome is poorly understood. Here, we demonstrate a strategy to disentangle and quantify distinct mechanisms underlying genome evolution in single cells, dur ...

Glacier-fed streams are the cold, ultra-oligotrophic, and unstable streams that are fed by glacial meltwater. Despite these extreme conditions, they harbour a diverse and abundant microbial diversity that develops into biofilms, covering the boulders and s ...

Gene regulatory networks (GRNs) play a crucial role in an organism's response to changing environmental conditions. Cellular behaviors typically result from the integration of multiple gene outputs, and their regulation often demands precise control of num ...

The magnet feeders are part of the critical systems of a fusion reactor since they represent the interface between the in-cryostat components at 4.5 K and the room-temperature cryogenic plant and power supply. The European DEMO tokamak foresees 16 toroidal ...

This paper establishes a mean-field equation set and an energy theorem to provide a theoretical basis in view of the development of self-consistent, physics-based turbulent transport models for mean-field transport codes. A rigorous averaging procedure ide ...

The local physical properties - such as shape and flexibility - of the DNA double-helix is today widely believed to be influenced by nucleic acid sequence in a non-trivial way. Furthermore, there is strong evidence that these properties play a role in many ...

Automating experimental procedures has resulted in an unprecedented increase in the volume of generated data, which, in turn, has caused an accumulation of unprocessed data. As a result, the need to develop tools to analyze data systematically has been ris ...

What training should engineering students receive to enable them to contribute to reducing bias, discrimination and the persistent lack of diversity in engineering? Collaboration is central to professional engineering work and, consequently, teamwork and g ...

The notion that mitochondria cannot be lost was shattered with the report of an oxymonad Monocercomonoides exilis, the first eukaryote arguably without any mitochondrion. Yet, questions remain about whether this extends beyond the single species and how th ...

Neurotechnology applies methods and devices to mitigate the burden of neurological and mental disorders. In particular, neural interfaces establish a long-term, seamless, symbiotic integration between implants and neural tissue. Materials play a pivotal ro ...

CsSnI3 is a promising ecofriendly solution for energy harvesting technologies. It exists at room temperature in either a black perovskite polymorph or a yellow 1D double-chain, which irreversibly deteriorates in the air. In this work, we unveil the relativ ...

Large-scale kinetic metabolic models of Pseudomonas putida KT2440 for consistent design of metabolic engineering strategies

Chattez avec Graph Search

Synthesis and Activation of Heteroatom-Substituted Four-Membered Carbocycles

Reconstruction and analysis of genome-scale metabolic networks in single organisms and microbial communities

The impact of different methods of increasing the intensity of compassion in engineering ethics cases

“But of course i’m going to look happy” or “He needed to know I was angry”? Comparing use of emotional labour in teamwork in engineering and hospitality students

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Optimality principles for the analysis of biological processes across scales: From enzyme kinetics to microbiome dynamics

The cost of adaptability: resource availability constrains functional stability under pulsed disturbances

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012

First-principles thermodynamics of precipitation in aluminum-containing refractory alloys

Single-mitosis dissection of acute and chronic DNA mutagenesis and repair

The microbial genomics of glacier-fed streams: adaptations to an extreme ecosystem

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

The magnet feeders for the European DEMO fusion reactor: Conceptual design and recent advances

Mean-field transport equations and energy theorem for plasma edge turbulent transport

Landscapes of DNA Mechanics and Genomes

Modeling, analysis, and design of complex biological networks

Educating Engineering Students to Address Bias and Discrimination Within Their Project Teams

Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria

Engineering Materials for Neurotechnology

First-Principles Thermodynamics of CsSnI3