Publications associées à Institutional ELN/LIMS deployment Highly customizable ELN/LIMS platform as a cornerstone of digital transformation for life sciences research institutes

Publications associées (15)

GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis

Giovanni D'Angelo, Charlotte Julie Caroline Gehin, Laura Capolupo

The Golgi apparatus, the main glycosylation station of the cell, consists of a stack of discontinuous cisternae. Glycosylation enzymes are usually concentrated in one or two specific cisternae along the cis-trans axis of the organelle. How such compartment ...

WILEY2021

Dual-Activatable Cell Tracker for Controlled and Prolonged Single-Cell Labeling

Pablo Rivera Fuentes, Salome Riccarda Püntener

Cell trackers are fluorescent chemical tools that facilitate imaging and tracking cells within live organisms. Despite their versatility, these dyes lack specificity, tend to leak outside of the cell, and stain neighboring cells. Here, we report a dual-act ...

AMER CHEMICAL SOC2020

Macrophage interference on chemotherapy

Michele De Palma, Chiara Cianciaruso, Sina Nassiri

NATURE PUBLISHING GROUP2019

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro

Since most dominant human mutations are single nucleotide substitutions(1,2), we explored gene editing strategies to disrupt dominant mutations efficiently and selectively without affecting wild-type alleles. However, single nucleotide discrimination can b ...

NATURE PUBLISHING GROUP2019

Time Domain Near-Infrared Optical Tomography with Time-of-Flight SPAD Camera: The New Generation

Edoardo Charbon, Chunmin Zhang, Scott Anthony Lindner, Juan Mata Pavia

We present the first laboratory results of the new generation of time domain near-infrared optical tomography setup, which is based on a time-of-flight 32×32 SPAD camera with high photon detection probability in the NIR range. ...

2018

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Douglas Hanahan, Mohammad Sadegh Saghafinia

The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify a ...

2018

Photothermal Off-Resonance Tapping for Rapid and Gentle Atomic Force Imaging of Live Cells

Georg Fantner, John McKinney, Adrian Pascal Nievergelt, Haig Alexander Eskandarian, Charlène Cécile Geneviève Brillard

Imaging living cells by atomic force microscopy (AFM) promises not only high-resolution topographical data, but additionally, mechanical contrast, both of which are not obtainable with other microscopy techniques. Such imaging is however challenging, as ce ...

2018

Minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells

Jean-Jacques Meister, Alexander Verkhovskiy, Chiara Gabella, Franck Claude Raynaud, Alicia Carine Bornert, Mark Etienne Ambühl

How cells break symmetry and organize activity at their edges to move directionally is a fundamental question in cell biology. Physical models of cell motility commonly incorporate gradients of regulatory proteins and/or feedback from the motion itself to ...

Nature Publishing Group2016

Nanowire-Aperture Probe: Local Enhanced Fluorescence Detection for the Investigation of Live Cells at the Nanoscale

Anna Fontcuberta i Morral, Esther Alarcon Llado

Fluorescence microscopy has tackled many of the burning questions in cellular biology. Probing low-affinity cellular interactions remains one of the major challenges in the field to better understand cellular signaling. We introduce a novel approach the na ...

Amer Chemical Soc2016

The TORCH time-of-flight detector

Christoph Frei

The TORCH time-of-flight detector is being developed to provide particle identification between 2 and 10 GeV/c momentum over a flight distance of 10 m. TORCH is designed for large-area coverage, up to 30 m(2), and has a DIRC-like construction. The goal is ...

Elsevier Science Bv2016

Optimal Design of Signaling Modules : Key Drivers, Trade-Offs and Sustainability

Andrijana Radivojevic

One of the basic characteristics of every living system is the ability to respond to extracellular signals. This is carried out through a limited number of protein-based signaling networks, whose function is not based only on simple transmission of the rec ...

EPFL2012

Cellular Dynamics and Three-Dimensional Refractive Index Distribution Studied with Quantitative Phase Imaging

Nicolas Pavillon

We present in this PhD thesis work various applications of digital holographic microscopy (DHM), an imaging technique based on coherent illumination which enables the recovery of the full complex wavefront, i.e. the amplitude and phase of a wave field whic ...

EPFL2011

Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos

Pierre Gönczy, Coralie Busso

Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for c ...

Cell Press - Elsevier2009

Mechanical effects of alkali silica reaction in concrete studied by SEM-image analysis

Mohsen Ben Haha

The occurrence of alkali-silica and alkali-silicate reactions causes damage in concrete. Even though the reaction has been known for some time, the progress of reaction in affected structures is difficult to predict. This research programme aims to study t ...

EPFL2006

Etude et modélisation des effets écotoxiques d'un micropolluant organique sur "Daphnia magna" et "Pseudokirchneriella subcapitata"

Nathalie Chèvre Rossi

The aim of this work is the modelling of the effects of a pollutant on an organism including time as a variable. The model developed will permit the evaluation of the toxicity globally, at short or long term, for low or high concentrations. This approach w ...

EPFL2000