Institutional ELN/LIMS deployment Highly customizable ELN/LIMS platform as a cornerstone of digital transformation for life sciences research institutes

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The Golgi apparatus, the main glycosylation station of the cell, consists of a stack of discontinuous cisternae. Glycosylation enzymes are usually concentrated in one or two specific cisternae along the cis-trans axis of the organelle. How such compartment ...

Cell trackers are fluorescent chemical tools that facilitate imaging and tracking cells within live organisms. Despite their versatility, these dyes lack specificity, tend to leak outside of the cell, and stain neighboring cells. Here, we report a dual-act ...

Since most dominant human mutations are single nucleotide substitutions(1,2), we explored gene editing strategies to disrupt dominant mutations efficiently and selectively without affecting wild-type alleles. However, single nucleotide discrimination can b ...

We present the first laboratory results of the new generation of time domain near-infrared optical tomography setup, which is based on a time-of-flight 32×32 SPAD camera with high photon detection probability in the NIR range. ...

The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify a ...

Imaging living cells by atomic force microscopy (AFM) promises not only high-resolution topographical data, but additionally, mechanical contrast, both of which are not obtainable with other microscopy techniques. Such imaging is however challenging, as ce ...

How cells break symmetry and organize activity at their edges to move directionally is a fundamental question in cell biology. Physical models of cell motility commonly incorporate gradients of regulatory proteins and/or feedback from the motion itself to ...

Fluorescence microscopy has tackled many of the burning questions in cellular biology. Probing low-affinity cellular interactions remains one of the major challenges in the field to better understand cellular signaling. We introduce a novel approach the na ...

The TORCH time-of-flight detector is being developed to provide particle identification between 2 and 10 GeV/c momentum over a flight distance of 10 m. TORCH is designed for large-area coverage, up to 30 m(2), and has a DIRC-like construction. The goal is ...

One of the basic characteristics of every living system is the ability to respond to extracellular signals. This is carried out through a limited number of protein-based signaling networks, whose function is not based only on simple transmission of the rec ...

We present in this PhD thesis work various applications of digital holographic microscopy (DHM), an imaging technique based on coherent illumination which enables the recovery of the full complex wavefront, i.e. the amplitude and phase of a wave field whic ...

Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for c ...

The occurrence of alkali-silica and alkali-silicate reactions causes damage in concrete. Even though the reaction has been known for some time, the progress of reaction in affected structures is difficult to predict. This research programme aims to study t ...

The aim of this work is the modelling of the effects of a pollutant on an organism including time as a variable. The model developed will permit the evaluation of the toxicity globally, at short or long term, for low or high concentrations. This approach w ...

Institutional ELN/LIMS deployment Highly customizable ELN/LIMS platform as a cornerstone of digital transformation for life sciences research institutes

Chattez avec Graph Search

GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis

Dual-Activatable Cell Tracker for Controlled and Prolonged Single-Cell Labeling

Macrophage interference on chemotherapy

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

Time Domain Near-Infrared Optical Tomography with Time-of-Flight SPAD Camera: The New Generation

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Photothermal Off-Resonance Tapping for Rapid and Gentle Atomic Force Imaging of Live Cells

Minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells

Nanowire-Aperture Probe: Local Enhanced Fluorescence Detection for the Investigation of Live Cells at the Nanoscale

The TORCH time-of-flight detector

Optimal Design of Signaling Modules : Key Drivers, Trade-Offs and Sustainability

Cellular Dynamics and Three-Dimensional Refractive Index Distribution Studied with Quantitative Phase Imaging

Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos

Mechanical effects of alkali silica reaction in concrete studied by SEM-image analysis

Etude et modélisation des effets écotoxiques d'un micropolluant organique sur "Daphnia magna" et "Pseudokirchneriella subcapitata"