Publications associées à Cyclic peptide therapeutics: past, present and future

Cyclic Peptides for Drug Development

Christian Heinis, Xinjian Ji, Alexander Lund Nielsen

Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years ...

Wiley-VCH Verlag GmbH2024

Fungal mycelia: From innovative materials to promising products: Insights and challenges

Wenjing Sun

In transitioning toward a sustainable economy, mycelial materials are recognized for their adaptability, biocompatibility, and eco-friendliness. This paper updates the exploration of mycelial materials, defining their scope and emphasizing the need for pre ...

Aip Publishing2024

Geospatial Tools and Remote Sensing Strategies for Timely Humanitarian Response: A Case Study on Drought Monitoring in Eswatini

Jérôme Chenal

This article explores the escalating impact of natural disasters, particularly droughts, in the Southern African Development Community (SADC), with a specific focus on Eswatini. Over the last century, approximately 63 million people in SADC countries have ...

MDPI2024

Methods for high-throughput synthesis and screening of peptide libraries

Zsolt Bognár

Macrocycles provide an attractive modality for drug development but the identification of ligands to targets of interest is hindered by the lack of large macrocyclic compound libraries for high-throughput screening. A strategy to efficiently synthesize lar ...

EPFL2024

Impact of substrate clogging on vertical connectivity

Giovanni De Cesare, Romain Maxime Dubuis, Robin Schroff

Connectivity between the hyporheic zone and the flow is essential for the development of benthos and the reproductive success of spawning fish. The infiltration of fine sediment leads to clogging of the riverbed, reducing porosity and vertical water exchan ...

2023

Swiss dams: Overview of historical development

Anton Schleiss

With more than 220 large dams in operation, compared to its surface of some 41ʹ000 km2, Switzerland has a very large fleet. They were erected to meet various economic and protection needs. Their main assignments concern the storage of water for later use, ...

CRC Press/Balkema2023

Determinants of urban environmental quality in Morocco: The roles of energy consumption, urbanization, manufacturing, and financial development in SDG 13

Jérôme Chenal, Hassan Radoine

Studies on urban environmental quality are evolving emphasizing the need for policy response concerning the enactment of environmental regulations to attain sustainable development goals (SDGs), mainly target 13. Over the years, the concerns to improve urb ...

FRONTIERS MEDIA SA2023

Advances in hydration and thermodynamics of cementitious systems

Patrick Juilland, Karen Scrivener, Aslam Kunhi Mohamed, Thomas Matschei, Fabien Jacques Michel Georget

Optimising the hydration of cementitious materials is crucial to leverage their full potential and avoid wasting resources, embodied energy and CO2. Understanding the fundamental mechanisms is key to reach these objectives. In this paper, we review progres ...

Pergamon-Elsevier Science Ltd2023

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Paul Joseph Dyson, Irina Sinenko, Roland Christopher Turnell-Ritson

Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2023

Roadmap on Machine learning in electronic structure

Michele Ceriotti, Andrea Grisafi, Max David Veit, Jigyasa Nigam

In recent years, we have been witnessing a paradigm shift in computational materials science. In fact, traditional methods, mostly developed in the second half of the XXth century, are being complemented, extended, and sometimes even completely replaced by ...

IOP Publishing Ltd2022

On the development of multi-physics tools for nuclear reactor analysis based on OpenFOAM (R): state of the art, lessons learned and perspectives

Carlo Fiorina

In the last two decades, the use of OpenFOAM as a multi-physics library for nuclear applications has grown from a sporadic use for exploratory studies to a widespread application for the analysis of innovative reactor concepts and highly complex problems. ...

ELSEVIER SCIENCE SA2022

Towards Beam-Beam Simulations for FCC-ee

Tatiana Pieloni, Xavier Buffat, Péter Kicsiny, Mike Seidel, Giovanni Iadarola

The FCC-ee (Future Circular Collider) lepton collider is currently the most favored next generation research infrastructure project at CERN, aimed at studying properties of standard model particles with the highest precision ever. The chosen parameters of ...

JACoW Publishing, Geneva, Switzerland2022

Exploring Photoredox-Catalyzed (Re)functionalizations with Core-Modified Benziodoxolones

Jérôme Waser, Franck Le Vaillant, Stephanie Grace Elizabeth Amos

Alkynes and nitriles are valuable building blocks in organic synthesis and also have multiple applications in chemical biology and materials science. Due to the high availability of tertiary alcohols, developing methods for their conversion into alkynes an ...

2022

Material Development for Perovskite/Silicon Tandem Photovoltaics

Peter Joseph Fiala

The developed world is built on the fact that energy is readily available and functionally infinite. The electricity from the wall, the gas at the station, and the heat in our homes are reliable and low-cost. But this comfort is so far only possible throug ...

EPFL2022

Code Generation Approach Supporting Complex System Modeling based on Graph Pattern Matching

Dimitrios Kyritsis, Yan Yan, Jinzhi Lu

Code generation is an effective way to drive the complex system development in model-based systems engineering. Currently, different code generators are developed for different modeling languages to deal with the development of systems with multi-domain. T ...

ELSEVIER2022

The CT-cube: A framework for the design and the assessment of computational thinking activities

Francesco Mondada, Laila Abdelsalam El-Hamamsy, Alberto Piatti

Computational thinking is a fundamental competence that is being introduced in K-12 and succeeding curricula worldwide. Despite this huge effort, many computational thinking models in the literature do not explicitly take into consideration the pupils’ age ...

2022

UAV in the advent of the twenties: Where we stand and what is next

Jan Skaloud, Davide Antonio Cucci

The use of Unmanned Aerial Vehicles (UAVs) has surged in the last two decades, making them popular instruments for a wide range of applications, and leading to a remarkable number of scientific contributions in geoscience, remote sensing and engineering. H ...

2022

Assessing Computational Thinking: Development and Validation of the Algorithmic Thinking Test for Adults

Olivier Lévêque, Jessica Elke Dehler Zufferey, Cécile Hardebolle, Marc Lafuente Martinez

This study describes the development and validation process of a computational thinking (CT) test for adults. The team designed a set of items and explored a subset of those through two qualitative pilots. Then, in order to provide validity evidence based ...

2022

Transnational Expertise and Local Policies for the Architecture of Spanish Tourism Industry

Sila Karatas

This chapter discusses the political, economic and spatial encounters between transnational networks and national structures behind the raise of international tourist trade and local industry in the 1960s Spain. Through a cross-reading between the privatiz ...

Routledge2022

De novo developed small cyclic peptides that are orally available

Manuel Leonardo Merz

Cyclic peptides are ring-shaped molecules that emerged as a promising class of therapeutics. While it is often difficult to find small molecule binders for challenging disease targets, cyclic peptides can bind to featureless surfaces or inhibit protein-pro ...

EPFL2022