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Self-Organizing Configurable Bit Slice Processors

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Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...

2023

Information Theory in Transmembrane Transport

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The past decades have seen the advent of information theory in various fields, from quantum physics to cosmology. At an intermediary scale between atomic and cosmological scales are biological systems and in particular the cell, as a constitutive element o ...

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The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing our understanding of biological processes, not just by studying its similarities with other organisms including ourselves but also by investigating its differences to u ...

Genetics Society America2023

Industrial Biotechnology Conservation Processes: Similarities with Natural Long-Term Preservation of Biological Organisms

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Cryopreservation and lyophilization processes are widely used for conservation purposes in the pharmaceutical, biotechnological, and food industries or in medical transplantation. Such processes deal with extremely low temperatures (e.g., -196 degrees C) a ...

MDPI2023

Dissecting centriole fate in C. elegans development

Nils Kalbfuss

The presence of centrioles is critical for fundamental cell and developmental processes, including polarity, migration and division. Although centrioles are present in most proliferating cells, they are thought to vanish after cell cycle exit in some diffe ...

EPFL2022

Microfluidic culture platforms for C. elegans bacterial interaction and digestion studies at single-organism resolution

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Increasing interest in understanding fundamental biological processes, among which aging and nutrition, has led to the study of simple and powerful model organisms, as the round-worm Caenorhabditis elegans (C. elegans). The nematode, selected by Sydney Bre ...

EPFL2021

Nanomechanical bio-sensing for fast and reliable detection of viability and susceptibility of microorganisms

Giovanni Dietler, Raphaël Foschia, Sandor Kasas, María Inés Villalba, Leonardo Venturelli

The metabolic activity of living organisms results in cellular motion on a nanometric scale that can be efficiently detected by micro- and nano- fabricated sensors. Quartz crystal microbalance and atomic force microscopy (AFM) inspired techniques have rece ...

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A perspective view on the nanomotion detection of living organisms and its features

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The insurgence of newly arising, rapidly developing health threats, such as drug-resistant bacteria and cancers, is one of the most urgent public-health issues of modern times. This menace calls for the development of sensitive and reliable diagnostic tool ...

WILEY2020

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The discovery of carbon-based nanomaterials has impacted a variety of research areas in ways that could not be imagined three decades ago. Their unique combination of structural, optical, and electronic properties has made these nano-sized materials partic ...

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The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells

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Precise spatiotemporal regulation of gene expression is essential for development and homeostasis of complex organisms. This is achieved in large part by sequence-specific transcription factors (TF) that bind to genomic regulatory elements to activate or r ...

EPFL2019

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DNA-protein interactions play an important role in all living organisms on Earth. The advent of atomic force microscopy permitted for the first time to follow and to characterize interaction forces between these two molecular species. After a short descrip ...

Elsevier2018

Human and eco-toxicological impacts of organometallic halide perovskites

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Solar radiation currently represents the most important source of renewable energy. Existing technologies to collect and distribute solar energy are expensive, difficult to manufacture, non-recyclable and not very cost-effective. Recent advances in physics ...

EPFL2017

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SPIE Society of Photo-optical Instrumentation Engineers2016

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Christian Santschi, Olivier Martin, Volodymyr Koman

The continuous measurement of uptake or release of biomarkers provides invaluable information for understanding and monitoring the metabolism of cells. In this work, a multiscattering-enhanced optical biosensor for the multiplexed, non-invasive, and contin ...

Optical Soc Amer2015

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Andrea Rinaldo, Amos Maritan

Despite the vast diversity of sizes and shapes of living organisms, life's organization across scales exhibits remarkable commonalities, most notably through the approximate validity of Kleiber's law, the power law scaling of metabolic rates with the mass ...

National Academy of Sciences2014

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National Academy of Sciences2014

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EPFL2014

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Public Library Science2013

A transcript perspective on evolution

Yann Christinat, Bernard Moret

Alternative splicing is now recognized as a major mechanism for transcriptome and proteome diversity in higher eukaryotes, yet its evolution is poorly understood. Most studies focus on the evolution of exons and introns at the gene level, while only few co ...

Ieee Computer Soc2013

Model Organisms Proteomics-From Holobionts to Human Nutrition

Martin Kussmann

Model organisms are an important tool for the development and validation of analytical approaches for proteomics and for the study of basic mechanisms of biological processes. The Initiative on Model Organism Proteomics (iMOP) organized a session during th ...

Wiley-Blackwell2013