Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

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Bacteria are ubiquitous single cellular organisms. Compared to eukaryotic cells, bacteria have two unique characteristics: the membrane-less nucleoid and the cell wall built of peptidoglycan (PG). In most bacteria, a single circular chromosome is compacted ...

As large, data-driven artificial intelligence models become ubiquitous, guaranteeing high data quality is imperative for constructing models. Crowdsourcing, community sensing, and data filtering have long been the standard approaches to guaranteeing or imp ...

Gels made of telechelic polymers connected by reversible cross-linkers are a versatile design platform for biocompatible viscoelastic materials. Their linear response to a step strain displays a fast, near-exponential relaxation when using low-valence cros ...

Mycobacterium Tuberculosis is a highly effective pathogen infecting nearly a third of the world's population. An M. tuberculosis infection starts when droplets containing bacteria enter an individual's lungs. The first host cells to contact the bacteria ar ...

Ribosomes translate the genetic code into proteins. Recent technical advances have facilitated in situ structural analyses of ribosome functional states inside eukaryotic cells and the minimal bacterium Mycoplasma. However, such analyses of Gram-negative b ...

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

The World Health Organization highlights the urgent need to address the global threat posed by antibiotic-resistant bacteria. Efficient and rapid detection of bacterial response to antibiotics and their virulence state is crucial for the effective treatmen ...

The present study aimed to fill the knowledge gap between the implications of intracellular and extracellular antibiotic resistance mechanisms may inflict on the inactivation pathways of the photo-Fenton process under mild conditions. It was thus designed ...

BackgroundAging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does not fully explain ...

We propose Reconfigurable Umbrella Meshes (RUMs), a new class of preassembled deployable structures. A RUM has a compact rest state that can be easily altered to deploy into different bending-active 3D target shapes. RUMs consist of elastic beams and rigid ...

The abusive use of antimicrobial drugs during the last eighty years has favoured the natural selection of resistant pathogens able to neutralise drugs efficiently. Nowadays, antimicrobial resistance contributes to millions of deaths yearly, threatens the e ...

Hydrogels are among the first materials expressly designed for their use in biomedicine. However, state-of-the-art applications of hydrogels are severely limited because they are typically either too soft or too brittle such that they cannot bear significa ...

A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded 'mycobacterial ...

Bacteria often colonize their environment in the form of surface attached multicellular communities called biofilms. Biofilms grow from surface-attached cells that undergo division while self-embedding in a viscoelastic matrix. Biofilms grow at the surface ...

Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...

A variety of physical inputs acts onto bacteria in nature. However, these are most often ignored in the studies of their physiology. There is now increasing evidence indicating that bacteria respond to physical stimuli, including mechanical forces. Yet, qu ...

Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...

Tuberculosis (TB) is a major global health challenge, with approximately 1.4 million deaths per year. There is still a need to develop novel treatments for patients infected with Mycobacterium tuberculosis (Mtb). There have been many large-scale phenotypic ...

Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outc ...

Single-walled carbon nanotubes (SWCNTs) have unique optoelectronic properties that make them suitable for applications ranging from phototherapy to imaging and sensing, but their uptake has mainly been explored in eukaryotic cells. Here the authors explore ...

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

Chattez avec Graph Search

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

Extensions of Peer Prediction Incentive Mechanisms

Valence can control the nonexponential viscoelastic relaxation of multivalent reversible gels

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Machine learning method for the classification of the state of living organisms' oscillations

Homogeneous vs. heterogeneous photo-Fenton elimination of antibiotic-resistant bacteria bearing intracellular or extracellular resistance: Do resistance mechanisms interfere with disinfection pathways?

Secondary structure of the human mitochondrial genome affects formation of deletions

RUM: Reconfigurable Umbrella Mesh

Antimicrobial susceptibility testing with integrated photonic crystal optical tweezers

Controlling the Microstructure and Composition of 3D Printed Soft Load-Bearing Hydrogels

Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome

Biofilm morphogenesis on soft hydrogels

Impact of population size on early adaptation in rugged fitness landscapes

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

Extensive programmed centriole elimination unveiled in C. elegans embryos

Machine Learning Models for Mycobacterium tuberculosis In Vitro Activity: Prediction and Target Visualization

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

Carbon nanotube uptake in cyanobacteria for near-infrared imaging and enhanced bioelectricity generation in living photovoltaics