Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment

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Plasma lipids are modulated by gene variants and many environmental factors, including diet-associated weight gain. However, understanding how these factors jointly interact to influence molecular networks that regulate plasma lipid levels is limited. Here ...

We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the su ...

T he inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. Whereas GAD67 is constitutively active and produces >90% of GABA in the central nervous system ...

Single metal ion-phospholipid complexes are observed in biphasic electrospray ionization mass spectrometry (BESI-MS) using a dual-channel microsprayer. Such a microsprayer makes it possible to put into contact two immiscible liquids within the Taylor cone. ...

Cytokinesis in Schizosaccharomyces pombe begins at mitotic entry, when the site of division is defined by formation of the contractile acto-myosin ring (CAR) at the cell cortex. Contraction of the CAR and formation of the division septum are triggered at t ...

Novel amphiphilic multi-arm star-block copolymers with a hyperbranched core, a hydrophobic inner shell, and a hydrophilic outer shell have been prepared from a commercial hyperbranched polyester macroinitiator by ring-opening polymerization of -caprolacton ...

Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment

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Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response

Protein target highlights in CASP15: Analysis of models by structure providers

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

Formation and study of single metal ion–phospholipid complexes in biphasic electrospray ionization mass spectrometry

Homoeostasis between the GTPase Spg1p and its GAP in the regulation of cytokinesis in S. pombe

Amphiphilic multi-arm star-block copolymers for encapsulation of fragrance molecules