Microfluidics for in vitro biomimetic shear stress-dependent leukocyte adhesion assays

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Localized sources of morphogens, called signalling centres, play a fundamental role in coordinating tissue growth and cell fate specification during organogenesis. However, how these signalling centres are established in tissues during embryonic developmen ...

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

Organoids, miniature tissues generated from self-organizing stem cells within three-dimensional (3D) extracellular matrices (ECM), have opened up exciting possibilities for in vitro studies of complex physiological processes. A key factor in the success of ...

Earthquakes i.e. frictional ruptures, are commonly described by singular solutions of shear crack motions. These solutions assume a square root singularity order around the rupture tip and a constant shear stress value behind it, implying scale-independent ...

We investigate the fluid-driven growth of a shear crack along a frictional discontinuity and its transition to hydraulic fracturing (sometimes referred to as hydraulic jacking) under plane-strain conditions. We focus on the case of a constant friction coef ...

Wyoming-type bentonite is one of the materials to be used as part of the Engineered Barrier System (EBS) in deep geological disposal facilities for the safe disposal of spent nuclear fuel.In the KBS-3 type repository, the canisters containing the spent fue ...

The understanding of cell-cell and cell-matrix interactions via receptor and ligand binding relies on our ability to study the very first events of their contact. Of particular interest is the interaction between a T cell receptor and its cognate peptide-m ...

Brillouin scattering in gas shows unmatched gain properties in hollow-core optical fibers filled at high pressure. Here, the gain characteristics are studied for two common gases, namely, N2 and CO2, which show distinct features and are compared to expecte ...

The dynamic of fine sediment in rivers is closely related to the interactions between fine particles, the riverbed and the flow conditions. The accumulation of fine sediment in the riverbed reduces vertical water exchanges and can have detrimental effects ...

Chimeric antigen receptors (CARs) are synthetic, transmembrane proteins that trigger immune cell signaling following their engagement. They have been first utilized in T cells and later in natural killer (NK) cells to redirect their cytotoxicity toward a s ...

Superionics are fascinating materials displaying both solid- and liquid-like characteristics: as solids, they respond elastically to shear stress; as liquids, they display fast-ion diffusion at normal conditions. In addition to such scientific interest, su ...

The hydromechanical response of a Wyoming-type bentonite (MX-80) and its interface with steel was studied in terms of shear resistance under different hydration levels. A series of shear tests under constant normal stress were performed in total suction co ...

Lymphomas are a group of heterogeneous blood cancers that arise from lymphocytes. The two primary clinical classifications of lymphomas are Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). In particular, B-cell lymphoma refers to the malignancies ...

Studying the role of molecularly distinct lipid species in cell signaling remains challenging due to a scarcity of methods for performing quantitative lipid biochemistry in living cells. We have recently used lipid uncaging to quantify lipid -pro-tein affi ...

G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13. However, our understanding of the G protein selectivity of GPCRs is incomplet ...

Offshore pipelines that transport hydrocarbons under high pressure and high temperature are usually thermally insulated to maintain an elevated temperature and prevent any heat loss to the surroundings. However, the temperatures at the outer-wall of the pi ...

Cancer is one of the leading causes of death globally. Immunotherapy represents one of the most promising cancer treatments inducing complete and durable responses in a fraction of cancer patients. Despite the unprecedented clinical success achieved by T c ...

The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor in the SYSCOL cohort, we ...

The impact of the parallel flow shear on the tokamak plasma stability and turbulent transport driven by the ion temperature gradient (ITG) modes is analyzed by means of local gyrokinetic numerical analyses. It is shown that the parallel flow shear increase ...

In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. This study invest ...

Microfluidics for in vitro biomimetic shear stress-dependent leukocyte adhesion assays

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Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development

Multimodal transcriptomic atlases of mouse spinal cord injury

Engineering hydrogel microenvironments for epithelial organoid culture

Frictional weakening leads to unconventional singularities during dynamic rupture propagation

Shearing and opening of a pre-existing discontinuity in response to fluid injection

Shear strength and shear stiffness analysis of compacted Wyoming-type bentonite

Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays

Study of backward Brillouin scattering in gas-filled anti-resonant fibers

Influence of the shear stress on fine sediment exchanges with the substrate using UVP measurements

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

Solids that are also liquids: elastic tensors of superionic materials

Hydro-mechanichal characterisation of bentonite/steel interfaces

Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node

Quantifying single-cell diacylglycerol signaling kinetics after uncaging

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Drained Clay-Pipe Interface Resistance at Low Normal Stresses and Elevated Temperatures

Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Effects of the parallel flow shear on the ITG-driven turbulent transport in tokamak plasmas

Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes