Publications associées à Cerebellar Connectomics Provide New Biomarkers in Early Multiple Sclerosis

Accurate Diagnosis of Cortical and Infratentorial Lesions in Multiple Sclerosis Using Accelerated Fluid and White Matter Suppression Imaging

Objectives: The precise location of multiple sclerosis (MS) cortical lesions can be very challenging at 3 T, yet distinguishing them from subcortical lesions is essential for the diagnosis and prognosis of the disease. Compressed sensing-accelerated fluid ...

LIPPINCOTT WILLIAMS & WILKINS2023

Deep learning-based analysis of multiple sclerosis lesions with high and ultra-high field MRI

Francesco La Rosa

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system and affects almost 3 million people worldwide. There is currently no cure for MS, and its symptoms, starting with fatigue and weakness, often progress over time ...

EPFL2022

Multi-centre classification of functional neurological disorders based on resting-state functional connectivity

Jonas Richiardi, Dimitri Nestor Alice Van De Ville

Background: Patients suffering from functional neurological disorder (FND) experience disabling neurological symptoms not caused by an underlying classical neurological disease (such as stroke or multiple sclerosis). The diagnosis is made based on reliable ...

ELSEVIER SCI LTD2022

3-Dimensional Fluid and White Matter Suppression Magnetic Resonance Imaging Sequence Accelerated With Compressed Sensing Improves Multiple Sclerosis Cervical Spinal Cord Lesion Detection Compared With Standard 2-Dimensional Imaging

Tobias Kober

Objectives Fluid and white matter suppression (FLAWS) is a recently proposed magnetic resonance sequence derived from magnetization-prepared 2 rapid acquisition gradient-echo providing 2 coregistered datasets with white matter- and cerebrospinal fluid-supp ...

LIPPINCOTT WILLIAMS & WILKINS2022

Steps parameters of elderly patients hospitalised for an acute medical illness in a Swiss University Hospital: an observational pilot study

Anisoara Ionescu, Francesco Tommasini

BACKGROUND: Objective mobility goals for elderly hospitalised medical patients remain debated. We therefore studied steps parameters of elderly patients hospitalised for an acute illness, to determine goals for future interventional trials and medical prac ...

SMW supporting association2022

Toward an objective assessment of mobility in clinical and daily activity settings

Arash Atrsaei

Quantification of mobility is the key to monitor the progression of mobility disorders as well as the effect of an intervention. Inertial measurement units (IMUs) with dedicated algorithms can quantify postural transitions and gait as the two key aspects o ...

EPFL2021

Altered anterior default mode network dynamics in progressive multiple sclerosis

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti, Anjali Bagunu Tarun, Younes Farouj, Giulia Bommarito

Background: Modifications in brain function remain relatively unexplored in progressive multiple sclerosis (PMS), despite their potential to provide new insights into the pathophysiology of the disease at this stage. Objectives: To characterize the dynamic ...

SAGE PUBLICATIONS LTD2021

Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity

Kamiar Aminian, Benoît Mariani, Farzin Dadashi, Arash Atrsaei

Gait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions prov ...

2021

RimNet: A deep 3D multimodal MRI architecture for paramagnetic rim lesion assessment in multiple sclerosis

Meritxell Bach Cuadra, Tobias Kober, Hamza Kebiri, Cristina Granziera, Po-Jui Lu, Francesco La Rosa

Objectives In multiple sclerosis (MS), the presence of a paramagnetic rim at the edge of non-gadolinium-enhancing lesions indicates perilesional chronic inflammation. Patients featuring a higher paramagnetic rim lesion burden tend to have more aggressive d ...

2020

Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing‐remitting multiple sclerosis

Jonas Richiardi, Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Dimitri Nestor Alice Van De Ville, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alessandro Daducci, Alexis Roche, Ying-Chia Lin

Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional ...

Wiley-Blackwell2015

Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis

Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alexis Roche, Ying-Chia Lin

Introduction. Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based ...

Hindawi Publishing Corporation2015

Multicontrats MRI Improved the Clinico-Radiological Correlation in Early Multiple Sclerosis Patients with Minor Deficits

Gloria Menegaz, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Guillaume Bonnier, David Paul Roger Romascano, Gunnar Krüger, Cristina Granziera, Alexis Roche, Ying-Chia Lin

Conventional magnetic resonance imaging (MRI) of patients with multiple sclerosis provides only limited insights into the nature of brain tissue damage with modest clinical-radiological correlations. In this study, quantitative and semi-quantitative MRI te ...

2014

Structural connectomics in brain diseases

Jean-Philippe Thiran, Patric Hagmann, Philipp Baumann, Alessandra Griffa

Imaging the connectome in vivo has become feasible through the integration of several rapidly developing fields of science and engineering, namely magnetic resonance imaging and in particular diffusion MRI on one side, image processing and network theory o ...

Elsevier2013

Functional Connectivity Eigennetworks Reveal Different Brain Dynamics In Multiple Sclerosis Patients

Jonas Richiardi, Dimitri Nestor Alice Van De Ville, Nora Leonardi

Resting state functional connectivity is defined as correlations in brain activity measured by functional magnetic resonance imaging without any stimulation paradigm. Such connectivity is dynamic, even over the course of minutes, and the development of too ...

Ieee2013

Structural Magnetic Resonance Imaging : Motion Correction and Improvement Strategies

Tobias Kober

Notwithstanding its great success in diagnostic routine and research, structural magnetic resonance imaging (MRI) still faces challenges. In this context, the present thesis studies new approaches to mitigate the motion susceptibility of MRI. Furthermore, ...

EPFL2011