The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

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The 70 kDa heat shock protein (Hsp70) chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) coevolved with Hsp70s to trigger ATP hydrolysis and catalytically upload various substrate polypeptides in ne ...

Mitochondria are essential organelles participating in numerous cellular functions, including energy harvesting, regulation of homeostasis and apoptosis. Changes in mitochondrial number, morphology, and function not only impact cellular metabolism but also ...

Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...

The Hsp70 cycle is a key element of protein homeostasis, which is essential to avoid protein aggregation and protein-related diseases. Despite many experimental observations of the interaction between Hsp70, its co-chaperone DnaJ and various substrates, li ...

Hsp60 chaperonins and their Hsp10 cofactors assist protein folding in all living cells, constituting the paradigmatic example of molecular chaperones. Despite extensive investigations of their structure and mechanism, crucial questions regarding how these ...

Computational models starting from large ensembles of evolutionarily related protein sequences capture a representation of protein families and learn constraints associated to protein structure and function. They thus open the possibility for generating no ...

This thesis consists of four Chapters unified by a singular theme â how do we develop disease models that faithfully reproduce the pathology seen in patients suffering from neurodegenerative disorders associated with the Tau protein, such as Alzheimerâ ...

Various endeavours into semantic web technologies and ontology engineering have been made within the organisation of cultural data, facilitating public access to digital assets. Although models for conceptualising objects have reached a certain level of ma ...

Purpose: Despite being an authentic carrier of various cultural practices, the human body is often underutilised to access the knowledge of human body. Digital inventions today have created new avenues to open up cultural data resources, yet mainly as appa ...

Solving native structures of such large molecules, like biomolecules, is often challenging, particularly due to the potentially infinite number of non-covalent interactions with water. In this thesis, we report the use of cold ion gas-phase action spectros ...

Detailed understanding of the mechanism by which Hsp70 chaperones protect cells against protein aggregation is hampered by the lack of a comprehensive characterization of the aggregates, which are typically heterogeneous. Here we designed a reporter chaper ...

The J-domain proteins (JDP) form the largest protein family among cellular chaperones. In cooperation with the Hsp70 chaperone system, these co-chaperones orchestrate a plethora of distinct functions, including those that help maintain cellular proteostasi ...

Abnormal tau protein aggregates constitute a hallmark of Alzheimer's disease. The mechanisms underlying the initiation of tau aggregation in sporadic neurodegeneration remain unclear. Here we investigate whether a non-human prion can seed tau aggregation. ...

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Increasing the protein production capacity of the PURE cell-free transcription-translation (TX-TL) system will be key to implementing complex synthetic biological circuits, and to establishing a fully self-regenerating system as a basis for the development ...

A Concideration of Typologies for Housing the Sick as a Spatial Manifestation of knowledge. ...

With the application requirements of wireless technology in implantable bioelectronics, knowledge of the fundamental limits for implanted antennas becomes critical. In this work, we investigated the variation of maximum power density within simplified body ...

In this thesis, we present a theory of value for the design and analysis of service ecosystems. The theory is based on general systems thinking. The concept of a system is used for relating knowledge from different disciplines (such as software engineering ...

Synucleinopathies such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy (MSA) are detrimental neurodegenerative diseases. Alpha-synuclein (aSyn), the main aggregating protein found in the pathological inclusions of these ailmen ...

In this article, we propose a novel approach for the localization of electromagnetic interference (EMI) sources based on the concept of compressive sensing and metalenses. We show that using the spatial and frequency dispersion offered by the metalens, we ...

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

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Autorepression of yeast Hsp70 cochaperones by intramolecular interactions involving their J-domains

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

Why do we need so many proteins? A physical insight into the collaboration of Hsp70 and DnaJ

A molecular device for the redox quality control of GroEL/ES substrates

Generative power of a protein language model trained on multiple sequence alignments

Deconstructing and Reconstructing the Complexity of Tau pathology

Building a Knowledge Graph of Chinese Kung Fu Masters From Heterogeneous Bilingual Data

Unlocking a multimodal archive of Southern Chinese martial arts through embodied cues

Bridging Native and Intrinsic Structures of Microhydrated Biomolecules by Cold Ion Spectroscopy

A fluorescent multi-domain protein reveals the unfolding mechanism of Hsp70

J-domain protein chaperone circuits in proteostasis and disease

Trans‐seeding of Alzheimer‐related tau protein by a yeast prion

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Improved Cell-Free Transcription-Translation Reactions in Microfluidic Chemostats Augmented with Hydrogel Membranes for Continuous Small Molecule Dialysis

Horizontal Healing

On the Maximum Power Density of Implanted Antennas within Simplified Body Phantoms

A Theory of Value for Service Ecosystems

Capturing the heterogeneity of alpha-synuclein pathology in synucleinopathies

A Compressive Sensing Framework for EMI Source Localization Using a Metalens Structure: Localization Beyond the Diffraction Limit