Publications associées à Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Publications associées (10)

Probing and modulating inter-areal coupling in the cortical visual motion processing pathway with non-invasive brain stimulation

In the last few years, stroke ranked as the second most common cause of death and is the third most significant condition affecting disability-adjusted life years (DALYs) worldwide. Being the most prevalent and quality of life impacting post-stroke symptom ...

EPFL2024

Changes Over Time in the Electrode/Brain Interface Impedance: An Ex-Vivo Study

Sandro Carrara, Diego Ghezzi, Gian Luca Barbruni

Closed-loop neural implants based on continuous brain activity recording and intracortical microstimulation are extremely effective and promising devices to monitor and address many neurodegenerative diseases. The efficiency of these devices depends on the ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2023

Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy

Maria del Carmen Sandi Perez, Jocelin Grosse

Creatine (Cr) is a nitrogenous organic acid and plays roles such as fast phosphate energy buffer to replenish ATP, osmolyte, antioxidant, neuromodulator, and as a compound with anabolic and ergogenic properties in muscle. Cr is taken from the diet or endog ...

WILEY2022

Sensory modulation of gait characteristics in human locomotion: A neuromusculoskeletal modeling study

Auke Ijspeert, Andrea Di Russo, Dimitar Yuriev Stanev

The central nervous system of humans and other animals modulates spinal cord activity to achieve several locomotion behaviors. Previous neuromechanical models investigated the modulation of human gait changing selected parameters belonging to CPGs (Central ...

2021

Deconvolution of Sustained Neural Activity From Large-Scale Calcium Imaging Data

Dimitri Nestor Alice Van De Ville, Fikret Isik Karahanoglu, Younes Farouj

Recent technological advances in light-sheet microscopy make it possible to perform whole-brain functional imaging at the cellular level with the use of Ca2+ indicators. The outstanding spatial extent and resolution of this type of data open unique opportu ...

Institute of Electrical and Electronics Engineers2020

Development and application of dynamic functional connectivity methods to elucidate the neural underpinnings of human behaviour with functional magnetic resonance imaging

Thomas William Arthur Bolton

Human behaviour is exquisitely complex, because it is staggeringly multi-facetted and subtly varies across individuals. Characterising its yet incompletely understood underlying biological mechanisms has profound clinical implications. Here, our goal was t ...

EPFL2020

Multi-Scale Modeling Of Photopolymerization For Medical Hydrogel-Implant Design

Jan-Anders Edvin Maansson, Dominique Pioletti, Pierre-Etienne Bourban, Salma Farahi, Andreas Schmocker, Azadeh Khoushabi

We report on the modeling of a photopolymerizable hydrogel and its application as a replacement of the interior of the intervertebral disc (so called Nucleus Pulposus). The hydrogel is initially injected in its liquid form and then photopolymerized via a s ...

Spie-Int Soc Optical Engineering2013

Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters

Denis Duboule

The importance of Hox genes in the specification of neuronal fates in the spinal cord has long been recognized. However, the transcriptional controls underlying their collinear expression domains remain largely unknown. Here we show in mice that the corres ...

2012

Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease

Motor dysfunction, cognitive impairment, and regional cortical atrophy indicate cerebral cortical involvement in Huntington disease (HD). To address the hypothesis that abnormal corticostriatal connectivity arises from polyglutamine-related alterations in ...

Lippincott, Williams & Wilkins2010

Design and control of amphibious robots with multiple degrees of freedom

Alessandro Crespi

This thesis presents the design and realization of two generations of robot elements that can be assembled together to construct amphibious mobile robots. These elements, designed to be individually waterproof and having their own battery, motor controller ...

EPFL2007