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Simple and Rapid Method To Determine Antimycobacterial Potency of Compounds by Using Autoluminescent Mycobacterium tuberculosis

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Publications associées (33)

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Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

John McKinney, Chiara Toniolo, Ophélie Rutschmann

Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outc ...

AMER SOC MICROBIOLOGY2022

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Challenges and Opportunities of Edge AI for Next-Generation Implantable BMIs

Mahsa Shoaran, Mohammad Ali Shaeri, Arshia Afzal

Neuroscience and neurotechnology are currently being revolutionized by artificial intelligence (AI) and machine learning. AI is widely used to study and interpret neural signals (analytical applications), assist people with disabilities (prosthetic applica ...

IEEE2022

Reliable Dispatch of Active Distribution Networks via a Two-layer Grid-Aware Model Predictive Control: Theory and Experimental Validation

Mario Paolone, Rahul Kumar Gupta, Antonio Zecchino, Ji Hyun Yi

Dispatching active distribution networks (ADNs) is an energy-intensive application that, if implemented via battery-energy storage systems (BESSs), can require a large capacity of these assets in order to fully balance the uncertainties caused by the stoch ...

2022

Bidirectional bionic limbs: a perspective bridging technology and physiology

Silvestro Micera

Precise control of bionic limbs relies on robust decoding of motor commands from nerves or muscles signals and sensory feedback from artificial limbs to the nervous system by interfacing the afferent nerve pathways. Implantable devices for bidirectional co ...

IOP Publishing Ltd2022

Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis

Stewart Cole, Charlotte Avanzi

Author summaryLeprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae, an obligate intracellular bacterium. Diagnosis of leprosy often relies on skin examinations for clinical signs, bacilli staining from skin smears and invasive s ...

PUBLIC LIBRARY SCIENCE2022

A modular strategy for next-generation upper-limb sensory-motor neuroprostheses

Silvestro Micera, Solaiman Shokur, Giuseppe Schiavone

Neuroprosthetics is a discipline that aims at restoring lost functions to people affected by a variety of neurological disorders or neuro-traumatic lesions. It combines the expertise of computer science and electrical, mechanical, and micro/nanotechnology ...

ELSEVIER2021

Positioning Left-hand Movement in Violin Performance: A System and User Study of Fingering Pattern Generation

Su Li

Organizing fingerings, i.e., choosing which fingers to press on which positions and strings, is a crucial step for playing the violin. As the violin fingering comprises several components, the mapping of a musical phrase to the corresponding fingering arra ...

ASSOC COMPUTING MACHINERY2021

Grammar-based generation of bar networks in static equilibrium with bounded bar lengths

Corentin Jean Dominique Fivet, Ioannis Mirtsopoulos

This paper presents a generative approach for the conceptual design of structures, which aims at exploring alternative bar networks in static equilibrium by means of a grammar rule. Operating on incomplete networks of bars in interim static equilibrium, th ...

2021

Assessing the energy potential of modernizing the European hydropower fleet

Anton Schleiss, Elena Vagnoni

About 50% of all hydropower plants (HPPs) worldwide were originally commissioned more than 40 years ago, so that the advanced age of the fleet is a major concern across all continents, and especially in Europe. The modernization of HPPs can generate severa ...

Elsevier2021

Dissipative Kerr solitons in a photonic dimer on both sides of exceptional point

Tobias Kippenberg, Hairun Guo, Mikhail Churaev, Alexey Tikan, Aleksandr Tusnin

Exceptional points are a ubiquitous concept widely present in driven-dissipative coupled systems described by a non-Hermitian Hamiltonian. To date, exceptional points have been extensively examined in the systems supporting only a few optical modes, thereb ...

NATURE RESEARCH2021

System and method for high beam quality pulse generation in mode-locked multimode fiber lasers

Demetri Psaltis, Christophe Moser, Ugur Tegin

A system and method to generate ultrashort high beam quality pulses from spatio- temporally mode-locked multimode fiber laser are described. The invention relies on engineering the intra-cavity pulse propagation in a multimode laser cavity to shape the spa ...

2021

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

Vassily Hatzimanikatis, Noushin Hadadi, Jasmin Maria Hafner, Anush Chiappino-Pepe, Homa Mohammadi Peyhani

The discovery of a drug requires over a decade of intensive research and financial investments – and still has a high risk of failure. To reduce this burden, we developed the NICEdrug.ch resource, which incorporates 250,000 bioactive molecules, and studied ...

2021