Preclinical development of a humanized chimeric antigen receptor against B-cell maturation antigen for multiple myeloma

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Elevated peripheral blood and tumor-infiltrating neutrophils are often associated with a poor patient prognosis. However, therapeutic strategies to target these cells are difficult to implement due to the life-threatening risk of neutropenia. In a genetica ...

High-throughput testing of photoelectrochemical cells and materials under well-defined operating conditions can accelerate the discovery of new semiconducting materials, the characterization of the phenomena occurring at the semiconductor-electrolyte inter ...

The elderly population is highly susceptible to developing respiratory diseases, including tuberculosis, a devastating disease caused by the airborne pathogen Mycobacterium tuberculosis ( M.tb ) that kills one person every 18 seconds. Once M.tb reaches the ...

Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial for people suffering from pathologies with impaired social behavior. Our aim was to study the brain activit ...

Background aims: Age-related macular degeneration (AMD) is the most common cause of blindness in elderly patients within developed countries, affecting more than 190 million worldwide. In AMD, the retinal pigment epithelial (RPE) cell layer progressively d ...

Mechanical residual stresses within multilayer thin-film device stacks become problematic during thermal changes because of differing thermal expansion and contraction of the various layers. Thin-film photovoltaic (PV) devices are a prime example where thi ...

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit a ...

The number of transient operations in hydraulic machinery connected to power grid, notably start-ups and shut-downs, has observed a substantial increase in recent decades, primarily driven by the global shift toward intermittent renewable energy sources. S ...

Cancer immunotherapy has become an attractive strategy among different therapeutic modalities over the past few years and has showed great success in the clinic. However, there are many outstanding challenges hindering the current immunotherapies. In my Ph ...

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their t ...

Preclinical development of a humanized chimeric antigen receptor against B-cell maturation antigen for multiple myeloma

Chattez avec Graph Search

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

High-throughput parallel testing of ten photoelectrochemical cells for water splitting: case study on the effects of temperature in hematite photoanodes

Human alveolar lining fl uid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Stress Engineering for Mitigating Thermal Cycling Fatigue in Perovskite Photovoltaics

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

On the prediction of the induced damage by the start-up sequence of Francis turbines: On operational resilience framework

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis