Precursor molecule for the synthesis of d-luciferin

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Thousands of biochemical reactions with characterized activities are “orphan,” meaning they cannot be assigned to a specific enzyme, leaving gaps in metabolic pathways. Novel reactions predicted by pathway-generation tools also lack associated sequences, l ...

Knudsen flow experiments and its interpretation in terms of adsorption/desorption kinetics as well as quantitative uptake on substrates of interest is presented together with the description of critical design parameters of the Knudsen Flow Reactor (KFR). ...

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Thiol-mediated uptake is emerging as method of choice to penetrate cells. This study focuses on irreversible covalent inhibitors of thiol-mediated uptake. High-content high-throughput screening of the so far largest collection of hypervalent iodine reagent ...

Ions differ in their ability to salt out proteins from solution as expressed in the lyotropic or Hofmeister series of cations and anions. Since its first formulation in 1888, this series has been invoked in a plethora of effects, going beyond the original ...

Precursor molecule for the synthesis of d-luciferin

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Organ-specific biotransformation in salmonids: Insight into intrinsic enzyme activity and biotransformation of three micropollutants

Optimality principles for the analysis of biological processes across scales: From enzyme kinetics to microbiome dynamics

De novo designed proteins: a study in engineering novel folds and functions

Bioengineering human mini-intestines with in vivo-like complexity and function

Biological nanopores for single-molecule sensing

Generating macrocyclic inhibitors of protein-protein interactions

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories

Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

Systematic analysis of biomolecular binding reactions using microfluidic systems

Enzyme annotation for orphan and novel reactions using knowledge of substrate reactive sites

Flowing Gas Experiments Reveal Mechanistic Details of Interfacial Reactions on a Molecular Level at Knudsen Flow Conditions

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

Low-energy Electron Holography Microscope for Imaging of Single Molecules

High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition

Inhibition of Thiol‐Mediated Uptake with Irreversible Covalent Inhibitors

Beyond the Hofmeister Series: Ion-Specific Effects on Proteins and Their Biological Functions