Publications associées à Evaluation of the ray-casting analytical algorithm for pencil beam scanning proton therapy

Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways

H3K27M-mutant diffuse midline glioma (DMG) patients have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/ ...

2023

Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy

Olivier Michielin, Monia Guidi, Alexandre Wicky, Nadia Terranova, Daniel Abler, Federico Amato

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...

2023

Efficient and Accurate Physically-Based Differentiable Rendering

Delio Aleardo Vicini

Physically-based rendering algorithms generate photorealistic images of virtual scenes. By simulating light paths in a scene, complex physical effects such as shadows, reflections and volumetric scattering can be reproduced. Over the last decade, physicall ...

EPFL2022

A Correlation-Based Electromagnetic Time Reversal Technique to Locate Indoor Transient Radiation Sources

Farhad Rachidi-Haeri, Marcos Rubinstein, Zhaoyang Wang, Qi Li

To overcome the multipath interference in locating transient electromagnetic (EM) radiation sources in an indoor environment, we propose a criterion that calculates the correlation between back-propagated signals from observation points, to be used in EM t ...

Institute of Electrical and Electronics Engineers2021

Slope-Space Integrals for Specular Next Event Estimation

Wenzel Alban Jakob, Tizian Lucien Zeltner, Guillaume Rémi Bruno Loubet

Monte Carlo light transport simulations often lack robustness in scenes containing specular or near-specular materials. Widely used uni- and bidirectional sampling strategies tend to find light paths involving such materials with insufficient probability, ...

ASSOC COMPUTING MACHINERY2020

Reparameterizing Discontinuous Integrands for Differentiable Rendering

Wenzel Alban Jakob, Guillaume Rémi Bruno Loubet

Differentiable rendering has recently opened the door to a number of challenging inverse problems involving photorealistic images, such as computational material design and scattering-aware reconstruction of geometry and materials from photographs. Differe ...

ASSOC COMPUTING MACHINERY2019

Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome

Patrick Andreas Gonschorek

There is currently no approved treatment for Netherton syndrome, which is a severe, genetic skin disease characterized by chronic inflammation and excessive peeling of the skin. Even though the molecular disease mechanism has been assigned to the unopposed ...

EPFL2019

CFSpro: ray tracing for design and optimization of complex fenestration systems using mixed dimensionality approach

Jean-Louis Scartezzini, Andreas Schueler, André Gabriel Kostro, Mario Geiger

Advanced optical ray tracing software, CFSpro, was developed for the study and optimization of complex fenestration systems (CFSs). Using an algorithm mixing 2D and 3D approaches, accurate computation of large numbers of rays in extruded geometries can be ...

Optical Soc Amer2016

Advances in modeling of lower hybrid current drive

Joan Decker

First principle modeling of the lower hybrid (LH) current drive in tokamak plasmas is a longstanding activity, which is gradually gaining in accuracy thanks to quantitative comparisons with experimental observations. The ability to reproduce simulatenously ...

Iop Publishing Ltd2016

Caged luciferin probes for the bioluminescence imaging of nitroreductase and hydrogen sulfide in living animals

Anzhelika Vorobyeva

Molecular imaging advances our understanding of cellular and molecular functions within complex biological systems. The development of novel imaging probes that can be applied to answer fundamental biological questions, diagnose and monitor disease progres ...

EPFL2016

Microstructured glazing for daylighting, glare protection, seasonal thermal control and clear view

André Gabriel Kostro

The appropriate choice of glazing in a facade depends on many factors. They include amongst other criteria: location, orientation, climatic condition, energetic efficiency, usage of the building, required user comfort, and the architectural concept. On the ...

EPFL2015

On Micro Optical Elements for Efficient Light Diffusion

Roland Andreas Bitterli

Efficient light management is one of the key issues in modern energy conversion systems, be it to collect optical power or to redistribute light generated by high power light emitters. This thesis touches mainly on the subject of efficient light redistribu ...

EPFL2013

Solar radiation modelling for urban environments

Darren Robinson

In this paper we briefly describe three alternative techniques for modelling solar radiation in the urban context. These include the use of: (i) simple morphological parameters as indicators of radiation availability, (ii) a ray-tracing program in conjunct ...

Université de Technologie Compiègne2010

Effect of intelligent antennas on radio system planning and on mitigation

Juliane Iten Chaves Simoes

Smart antennas have been recently applied to improve the capacity and the performance of second generation wireless mobile communication systems. In general, smart antennas reduce the effects of multipath fading and improve the signal-to-noise-plus-interfe ...

EPFL2008

A Computer-Based Real-Time Simulation of Interventional Radiology

Hannes Bleuler, Lindo Robert Duratti, Ulrich Spälter, Fei Wang, Evren Samur

Interventional radiology is a minimally invasive procedure where thin instruments, guidewires and catheters or stents are steered through the patient’s vascular system under X- ray imaging for treatment of vascular diseases. The complexity of these procedu ...

2007

Segmentation fémorale par modèle déformable et programmation dynamique

Gaëtan Marti

This Ph.D thesis presents new paradigms in the field of segmentation by mean of deformable models. Classic model-based segmentation approach consists of iteratively deform complex models in the space of the scanner slices until the organ to segment is fitt ...

EPFL2007

Modelling and refining site-specific radiation damage in SAD/MAD phasing

Site-specific radiation damage on anomalously scattering sites can be used to generate additional phase information in standard single- or multi-wavelength anomalous diffraction (SAD or MAD) experiments. In this approach the data are kept unmerged, down to ...

2007

Experimental validation of simulation methods for bi-directional transmission properties at the daylighting performance level

Marilyne Andersen

The objective of this paper is to assess the capability of existing lighting simulation methods to predict the performance of Complex Fenestration Systems (CFS), whose potential in daylight and sunlight control make them an increasingly popular alternative ...

Elsevier2006

Holistic Radiation Modelling with a Fast Simplified Radiosity Algorithm

Darren Robinson

The radiant external environment may be described by two hemispheres, above and below the horizontal plane, which are discretised into patches of known solid angle. Occlusions to these patches may be combined and represented as some patch fraction for whic ...

2005

Bi-directional transmission properties of Venetian blinds: experimental assessment compared to ray-tracing calculations

Marilyne Andersen, Jean-Louis Scartezzini

An accurate evaluation of daylight distribution through advanced fenestration systems (complex glazing, solar shading systems) requires the knowledge of their Bidirectional light Transmission (Reflection) Distribution Function BT(R)DF. An innovative equipm ...

2005