Exploring Neural Cell Dynamics with Digital Holographic Microscopy

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How does the brain generate behavioral responses from sensory stimuli? This sensor-to-motor transformation is a fundamental question in systems neuroscience. While recent experiments have highlighted the complexity of neural representations across the cere ...

The human brain is a complex and dynamic physiological system that can be considered as a network of reciprocally interconnected systems localized in different brain regions. To fully characterize the brain's complex dynamics, it is essential to investigat ...

Fundamental properties of light unavoidably impose features on images collected using fluorescence microscopes. Accounting for these features is often critical in quantitatively interpreting microscopy images, especially those gathering information at scal ...

Quantum ghost imaging can be an important tool in making optical measurements. One of the most useful aspects of ghost imaging is the unique ability to correlate two sets of independently collected information. We aim to use the principles of ghost imaging ...

Instruction-tuning is a widely adopted finetuning method that enables large language models (LLMs) to generate output that more closely resembles human responses. However, no studies have shown that instruction-tuning actually teaches LLMs to process langu ...

The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine learni ...

Atomic force microscopy (AFM) is a widely used imaging tool for obtaining a variety of information for a range of samples. Although it was initially intended to serve as a method of observing very flat solid surfaces, its use expanded into several other fi ...

During fear learning, defensive behaviors like freezing need to be finely balanced in the presence or absence of threat-predicting cues (conditioned stimulus, CS). Nevertheless, the circuits underlying such balancing are largely unknown. Here, we investiga ...

The evolution of the 3D morphology is at the center of many relevant biological processes ranging from cellular differentiation to cancer invasion and metastasis. Microscopy techniques, such as electron microscopy (EM), super-resolution (SR) optical micros ...

This manuscript proposes a new dual-mode cell imaging system for studying the relationships between calcium dynamics and the contractility process of cardiomyocytes derived from human-induced pluripotent stem cells. Practically, this dual-mode cell imaging ...

Optical microscopy is an essential tool for biologists, who are often faced with the need to overcome the spatial and temporal resolution limitations of their devices to capture finer details. As upgrading imaging hardware is expensive, computational metho ...

Collaborative efforts between basic scientists, engineers, and clinicians are enabling translational epileptology. In this article, we summarize the recent advances presented at the International Conference for Technology and Analysis of Seizures (ICTALS 2 ...

Previous studies have identified topologically associating domains (TADs) as basic units of genome organization. We present evidence of a previously unreported level of genome folding, where distant TAD pairs, megabases apart, interact to form meta-domains ...

The discovery that human brain connectivity data can be used as a "fingerprint " to identify a given individual from a population, has become a burgeoning research area in the neuroscience field. Recent studies have iden-tified the possibility to extract t ...

Antibiotic resistance is nowadays a major public health issue. Rapid antimicrobial susceptibility tests (AST) are one of the options to fight this deadly threat. Performing AST with single-cell sensitivity that is rapid, cheap, and widely accessible, is ch ...

Conserved catabolic pathways operate to remove aberrant polypeptides from the endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best known are the ER-associated degradation (ERAD) pathways that control the retrotransloca ...

Time-resolved electron microscopy has made significant progress in recent years, with some groups now working on instruments that offer attosecond temporal resolution. While much of the research in the field revolves around the improvement of temporal reso ...

Reaching and manipulating objects are crucial tasks that allow proactive interaction with our surroundings. However, these functions are lost after neurological disorders or traumatic events that cause hand paralysis. Neuroprosthetic technologies are medic ...

The topic of this thesis is the development of new algorithmic reconstruction methods for quantitative phase imaging (QPI). In the past decade, advanced QPI has emerged as a valuable tool to study label-free biological samples and uncover their 3D structur ...

Recent years have seen considerable progress in understanding brain function, and in modulating it through real-time fMRI neurofeedback (NF). Inspired by these advances, paired with the unique possibility of inducing the clinically relevant Presence Halluc ...

Exploring Neural Cell Dynamics with Digital Holographic Microscopy

Chattez avec Graph Search

Capturing behavioral and neural variability in multi-area spiking neuronal network models

A Spatiotemporal Analysis of Brain Dynamics, a New Feature for Sleep and Seizure State Discrimination

Fluorescence microscopy: A statistics-optics perspective

Ghost imaging using two SPAD array detectors: a parameter study towards the realization of a 3D quantum microscope

Instruction-tuned LLMs with World Knowledge are More Aligned to the Human Brain

Computational drug development for membrane protein targets

Advancements in Nanomechanical Characterization and Biomolecular Imaging with Atomic force Microscopy

A striatal circuit balances learned fear in the presence and absence of sensory cues

Time-Resolved Scanning Ion Conductance Microscopy and Single-Molecule Spectroscopy

Automated Dual-Mode Cell Monitoring To Simultaneously Explore Calcium Dynamics and Contraction-Relaxation Kinetics within Drug-Treated Stem Cell-Derived Cardiomyocytes

Practical computational imaging by use of spatiotemporal light modulation: from simulations to applications in biological microscopy

From basic sciences and engineering to epileptology: A translational approach

Chromosome-level organization of the regulatory genome in the Drosophila nervous system

Task matters: Individual MEG signatures from naturalistic and neurophysiological brain states

Simple optical nanomotion method for single-bacterium viability and antibiotic response testing

ER-to-lysosome-associated degradation in a nutshell: mammalian, yeast, and plant ER-phagy as induced by misfolded proteins

Towards near-atomic resolution imaging of microsecond nanoscale dynamics

Neurotechnologies to restore hand functions

Nonlinear Inverse Problems in Quantitative Phase Imaging

Neuroengineering of hallucinations through fMRI neurofeedback: Understanding and modulating neural dynamics for the control of hallucinations in health and disease