Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans

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The ULK1 kinase complex plays a crucial role in autophagosome biogenesis. To identify interactors or regulators of ULK1 complex assembly influencing autophagosome biogenesis, we performed an interaction proteomics screen. Employing both affinity purificati ...

Mammalian tail length is controlled by several genetic determinants, among which are Hox13 genes, whose function is to terminate the body axis. Accordingly, the precise timing in the transcriptional activation of these genes may impact upon body length. Un ...

Bacteria are ubiquitous single cellular organisms. Compared to eukaryotic cells, bacteria have two unique characteristics: the membrane-less nucleoid and the cell wall built of peptidoglycan (PG). In most bacteria, a single circular chromosome is compacted ...

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...

During fear learning, defensive behaviors like freezing need to be finely balanced in the presence or absence of threat-predicting cues (conditioned stimulus, CS). Nevertheless, the circuits underlying such balancing are largely unknown. Here, we investiga ...

The classical Lagrangian of the Standard Model enjoys the symmetry of the full conformal group if the mass of the Higgs boson is put to zero. This is a hint that conformal symmetry may play a fundamental role in the ultimate theory describing nature. The o ...

In this thesis, we explored on-chip high-resolution imaging of the fate of intestinal bacteria and bacterial products in Caenorhabditis elegans (C. elegans). In the first part, we carried out high-resolution z-stack fluorescent imaging of Red Fluorescent P ...

Previous studies have identified topologically associating domains (TADs) as basic units of genome organization. We present evidence of a previously unreported level of genome folding, where distant TAD pairs, megabases apart, interact to form meta-domains ...

Conserved catabolic pathways operate to remove aberrant polypeptides from the endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best known are the ER-associated degradation (ERAD) pathways that control the retrotransloca ...

Regulation of cytokinesis is essential for the cell during its division cycle. Failure to do so can lead to aneuploidy, which can be fatal and lead to senescence or cancer. A useful model organism for studying cytokinesis in eukaryotes is Schizosaccharomyc ...

Microtubules, a critical component of the cytoskeleton, carry post-translational modifications (PTMs) that are important for the regulation of key cellular processes. Long-lived microtubules, in neurons particularly, exhibit both detyrosination of a-tubuli ...

Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the ...

The capacity to break symmetry and organize activity to move directionally is a fundamental property of eukaryotic cells. To explain the organization of cell-edge activity, models commonly rely on front-to-back gradients of functional components or regulat ...

Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the dev ...

The paradigm of second-order phase transitions (PTs) induced by spontaneous symmetry breaking (SSB) in thermal and quantum systems is a pillar of modern physics that has been fruitfully applied to out-of-equilibrium open quantum systems. Dissipative phase ...

We propose a model for combining the Standard Model (SM) with gravity. It relies on a nonminimal coupling of the Higgs field to the Ricci scalar and on the Palatini formulation of gravity. Without introducing any new degrees of freedom in addition to those ...

Asymmetric divisions that yield daughter cells of different sizes are frequent during early embryogenesis, but the importance of such a physical difference for successful development remains poorly understood. Here, we investigated this question using the ...

The concept of quasi-symmetry-a perturbatively small deviation from exact symmetry-is introduced and leads to topological materials with strong resilience to perturbations. ...

Using an SU(2) invariant finite-temperature tensor network algorithm, we provide strong numerical evidence in favor of an Ising transition in the collinear phase of the spin-1/2 J(1)-J(2) Heisenberg model on the square lattice. In units of J(2), the critic ...

Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans

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CTCF-dependent insulation of Hoxb13 and the heterochronic control of tail length

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Exact quantum conformal symmetry, its spontaneous breakdown, and gravitational Weyl anomaly

Microfluidic devices for automated analysis of ingested bacteria in the Caenorhabditis elegans intestine

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Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination

Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos

Analysis and Modeling of the Dynamics of Traction Forces during Cell Polarization and their Role in the Organization of Edge Activity

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo

Continuous dissipative phase transitions with or without symmetry breaking

Standard model meets gravity: Electroweak symmetry breaking and inflation

Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

Quasi-symmetry-protected topology in a semi-metal

Thermal Ising Transition in the Spin-1/2 J(1)-J(2) Heisenberg Model