Publications associées à Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

Bacteria are ubiquitous single cellular organisms. Compared to eukaryotic cells, bacteria have two unique characteristics: the membrane-less nucleoid and the cell wall built of peptidoglycan (PG). In most bacteria, a single circular chromosome is compacted ...

EPFL2024

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Alex Russell Lederer

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

EPFL2024

Extensive programmed centriole elimination unveiled in C. elegans embryos

Pierre Gönczy, Nils Kalbfuss

Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...

2023

Exact quantum conformal symmetry, its spontaneous breakdown, and gravitational Weyl anomaly

Mikhail Chapochnikov, Anna Tokareva

The classical Lagrangian of the Standard Model enjoys the symmetry of the full conformal group if the mass of the Higgs boson is put to zero. This is a hint that conformal symmetry may play a fundamental role in the ultimate theory describing nature. The o ...

American Physical Society2023

Microfluidic devices for automated analysis of ingested bacteria in the Caenorhabditis elegans intestine

Farzad Rezaeianaran

In this thesis, we explored on-chip high-resolution imaging of the fate of intestinal bacteria and bacterial products in Caenorhabditis elegans (C. elegans). In the first part, we carried out high-resolution z-stack fluorescent imaging of Red Fluorescent P ...

EPFL2023

Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4

Michael Grüner Vindfeldt

Regulation of cytokinesis is essential for the cell during its division cycle. Failure to do so can lead to aneuploidy, which can be fatal and lead to senescence or cancer. A useful model organism for studying cytokinesis in eukaryotes is Schizosaccharomyc ...

EPFL2023

Primary data for EPFL thesis "Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4"

Michael Grüner Vindfeldt

Regulation of cytokinesis is essential for the cell during its division cycle. Failure to do so can lead to aneuploidy, which can be fatal and lead to senescence or cancer. A useful model organism for studying cytokinesis in eukaryotes is Schizosaccharomyc ...

EPFL Infoscience2023

Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos

Pierre Gönczy, Fernando Romero Balestra

Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the ...

GENETICS SOCIETY AMERICA2023

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo

Samuel William Vernon

Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the dev ...

Nature Portfolio2023

Dissecting centriole fate in C. elegans development

Nils Kalbfuss

The presence of centrioles is critical for fundamental cell and developmental processes, including polarity, migration and division. Although centrioles are present in most proliferating cells, they are thought to vanish after cell cycle exit in some diffe ...

EPFL2022

Quasi-symmetry-protected topology in a semi-metal

Yi-Chiang Sun, Xiangwei Huang, Philip Johannes Walter Moll, Jonas De Jesus Diaz Gomez, Matthias Carsten Putzke, Chunyu Guo

The concept of quasi-symmetry-a perturbatively small deviation from exact symmetry-is introduced and leads to topological materials with strong resilience to perturbations. ...

NATURE PORTFOLIO2022

Thermal Ising Transition in the Spin-1/2 J(1)-J(2) Heisenberg Model

Frédéric Mila, Olivier Clément Romain Gauthé

Using an SU(2) invariant finite-temperature tensor network algorithm, we provide strong numerical evidence in favor of an Ising transition in the collinear phase of the spin-1/2 J(1)-J(2) Heisenberg model on the square lattice. In units of J(2), the critic ...

2022

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Özge Uysal Özdemir

All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...

EPFL2022

Unraveling looping efficiency of stochastic Cosserat polymers

Giulio Corazza, Raushan Singh

Understanding looping probabilities, including the particular case of ring closure or cyclization, of fluctuating polymers (e.g., DNA) is important in many applications in molecular biology and chemistry. In a continuum limit the configuration of a polymer ...

AMER PHYSICAL SOC2022

Landau levels of the Euler class topology

Oleg Yazyev, Yifei Guan

Two-dimensional systems with C2T (PT) symmetry exhibit the Euler class topology E is an element of Z in each two-band subspace realizing a fragile topology beyond the symmetry indicators. By systematically studying the energy levels of Euler insulating pha ...

AMER PHYSICAL SOC2022

Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"

Özge Uysal Özdemir

All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...

EPFL Infoscience2022

Carbon nanotube uptake in cyanobacteria for near-infrared imaging and enhanced bioelectricity generation in living photovoltaics

Vitalijs Zubkovs, Ardemis Anoush Boghossian, Alessandra Antonucci, Charlotte Elisabeth Marie Roullier, Nils Schürgers, Benjamin Paul Johanès Gabriel Lambert, Alice Judith Gillen, Melania Reggente, Mohammed Mouhib

Single-walled carbon nanotubes (SWCNTs) have unique optoelectronic properties that make them suitable for applications ranging from phototherapy to imaging and sensing, but their uptake has mainly been explored in eukaryotic cells. Here the authors explore ...

2022

Low-scale leptogenesis with flavour and CP symmetries

Marco Drewes, Juraj Klaric, Yannis Georis

We consider a type-I seesaw framework endowed with a flavour symmetry, belonging to the series of non-abelian groups increment (3 n(2)) and increment (6 n(2)), and a CP symmetry. Breaking these symmetries in a non-trivial way results in the right-handed ne ...

Springer Nature2022

Analysis and Modeling of the Dynamics of Traction Forces during Cell Polarization and their Role in the Organization of Edge Activity

Zeno Messi

The capacity to break symmetry and organize activity to move directionally is a fundamental property of eukaryotic cells. To explain the organization of cell-edge activity, models commonly rely on front-to-back gradients of functional components or regulat ...

EPFL2021

Continuous dissipative phase transitions with or without symmetry breaking

Fabrizio Minganti

The paradigm of second-order phase transitions (PTs) induced by spontaneous symmetry breaking (SSB) in thermal and quantum systems is a pillar of modern physics that has been fruitfully applied to out-of-equilibrium open quantum systems. Dissipative phase ...

IOP Publishing Ltd2021