Anticancer activity of tetracationic arene ruthenium metalla-cycles

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Publications associées (32)

Rh-I, Ir-III ,and Co-III Complexes with Atropchiral Biaryl Cyclopentadienyl Ligands: Syntheses, Structures, and Catalytic Activities

Nicolai Cramer, Gints Smits, Coralie Danielle Annick Duchemin

Chiral cyclopentadienyl (Cp-x) group 9 metal complexes have become versatile catalysts for a variety of efficient enantioselective C-H functionalizations. Atropchiral binaphthyl-derived Cp-x ligands having tuning options at the 3,3'-positions present a rob ...

2019

Molecular nanostructures based on polyfunctional clathrochelate complexes

Suzanne Maria Jansze

This thesis describes the design and synthesis of clathrochelate metalloligands for the construction of molecular nanostructures. The low synthetic effort, versatility and stability of the clathrochelate metalloligands makes them particularly suited to the ...

EPFL2019

Combining ultra-high resolution ion-mobility spectrometry with cryogenic IR spectroscopy for the study of biomolecular ions

Thomas Rizzo, Ahmed Ben Faleh, Robert Paul Pellegrinelli, Natalia Yalovenko, Stephan Warnke

Double-resonance spectroscopic schemes in combination with cryogenic ion traps are the go-to techniques when isomer-specific high-resolution spectra are required for analysis of molecular ions. Their limitation lies in the requirement for well-resolved, is ...

2019

Synthesis and Characterization of Coordination Cages Based on Clathrochelate Metalloligands

Giacomo Cecot

The work presented in this thesis focused on the synthesis and characterization of new metalloligands based on iron(II) clathrochelate complexes. Clathrochelates can be functionalized peripherally with donor groups capable of coordinating metal ions. The s ...

EPFL2019

Separation and Identification of Glycan Anomers Using Ultrahigh-Resolution Ion Mobility Spectrometry and Cryogenic Ion Spectroscopy

Thomas Rizzo, Ahmed Ben Faleh, Valeriu Scutelnic, Stephan Warnke

The analysis of carbohydrates, or glycans, is challenging for established structure-sensitive gas-phase methods. The multitude of possible stereo-, regio- and structural isomers make them substantially more complex to ana-lyze than DNA or proteins, and no ...

2019

Facile N-functionalization and strong magnetic communication in a diuranium(v) bis-nitride complex

Marinella Mazzanti, Ivica Zivkovic, Farzaneh Fadaei Tirani, Lucile Sylvie Danielle Chatelain, Luciano Barluzzi

Uranium nitride complexes are of high interest because of their ability to effect dinitrogen reduction and functionalization and to promote magnetic communication, but studies of their properties and reactivity remain rare. Here we have prepared in 73% yie ...

2019

Influence of Functionalized η6 -Arene Rings on Ruthenium(II) Curcuminoids Complexes

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel, Laure Debora Pittet, Agnese Petrini

A series of organometallic Ru(II) complexes containing functionalized η6‐arene ligands, together with curcumin and bisdemethoxycurcumin as O,O’‐chelating ligands and their RAPTA (ruthenium arene complexes bearing the 1,3,5‐triaza‐7‐phosphaadamantane ligand ...

2018

Combining Ion Mobility and Cryogenic Spectroscopy for Structural and Analytical Studies of Biomolecular Ions

Thomas Rizzo, Michael Zachary Kamrath

Ion mobility spectrometry (IMS) has become a valuable tool in biophysical and bioanalytical chemistry because of its ability to separate and characterize the structure of gas-phase biomolecular ions on the basis of their collisional cross section (CCS). It ...

2018

Synthesis and Characterization of a Water Stable Uranyl(V) Complex

Rosario Scopelliti, Anne-Sophie Chauvin, Marinella Mazzanti, Radmila Faizova

We have identified a polydentate aminocarboxylate ligand that stabilizes uranyl(V) in water. The mononuclear [UO2(dpaea)]X, (dpaeaH2 = Bis(pyridyl-6-methyl-2-carboxylate)-ethylamine; X = CoCp2*+ or X = K(2.2.2.cryptand) complexes have been isolated from an ...

2018

High-pressure NMR spectroscopic and calorimetric studies on formic acid dehydrogenation and carbon dioxide hydrogenation

Cornel Fink

Our current energy production is convenient and simple, but it is not sustainable. The negative impacts on our environment are omnipresent in the form of smog, extinction of species, and global warming. A major challenge of our generation is the transition ...

EPFL2018

CO2 as hydrogen vector - Transition metal diamine catalysts for selective HCOOH dehydrogenation

Gabor Laurenczy, Cornel Fink

The homogeneous catalytic dehydrogenation of formic acid in aqueous solution provides an efficient in situ method for hydrogen production, under mild conditions, and at an adjustable rate. We synthesized a series of catalysts with the chemical formula [Cp* ...

2017

Development of mass spectrometric methods to understand the mechanism of action of transition metal-based anticancer compounds

Fook Seng Ronald Lee

Metal based anti-cancer drugs (metallodrugs) such as cisplatin are a cornerstone of cancer chemotherapy. However, development of this class of compound has been hindered by our lack of understanding of how they function. This is mainly because existing met ...

EPFL2016

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