Cyclic Hypervalent Iodine Reagents and Iron Catalysts: The Winning Team for Late-Stage C-H Azidation

1+1=3: by combining the exceptional properties of benziodoxolone reagents and iron catalysts, Sharma and Hartwig have achieved an important breakthrough for the late-stage C-Hazidation of complex molecules. Nevertheless, moderate yields and selectivities were still observed for some substrates, and our understanding of the reaction mechanism remains underdeveloped. Indeed, the potential of combining base-metal catalysts and cyclic hypervalent iodine reagents for the discovery of new reactions has just begun to be investigated, and many more exciting discoveries await us in the future. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.