Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

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Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. Here we propose a set of molecular criteria for evaluating the naive ...

The roundworm Caenorhabditis elegans (C. elegans) is a powerful model organism for addressing fundamental biological questions related to human disease and aging. Its life cycle consists of an embryo stage, four larval stages that can be clearly distinguis ...

Mammalian Host-Cell Factor 1 (HCF-1), a transcriptional co-regulator, plays important roles during the cell-division cycle in cell culture, embryogenesis as well as adult tissue. In mice, HCF-1 is encoded by the X-chromosome-linked Hcfc1 gene. Induced Hcfc ...

Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays multiple and essential roles during the cell division cycle. Its inhibition in cultured cells leads to severe mitotic aberrancies and cell death. Whereas previous reports suggested that Plk1 ...

All organisms live within a given thermal range, but little is known about the mechanisms setting the limits of this range. We uncovered cellular features exhibiting signature changes at thermal limits in Caenorhabditis elegans embryos. These included chan ...

Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keepin ...

Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sp ...

Asymmetric cell division is essential for the generation of diversity during development and the function of stem cell lineages. The Caenorhabditis elegans zygote is an attractive model to investigate the mechanisms of spindle positioning during asymmetric ...

Centrosomes are the principal microtubule organizing center (MTOC) of animal cells and comprise a pair of centrioles surrounded by pericentriolar material (PCM). Centriole number must be carefully regulated to ensure bipolar spindle formation and thus fait ...

Gene expression changes may underlie much of phenotypic evolution. The development of high-throughput RNA sequencing protocols has opened the door to unprecedented large-scale and cross-species transcriptome comparisons by allowing accurate and sensitive a ...

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

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Molecular Criteria for Defining the Naive Human Pluripotent State

Versatile size-dependent sorting of C-elegans nematodes and embryos using a tunable microfluidic filter structure

Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification

Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies

Cellular hallmarks reveal restricted aerobic metabolism at thermal limits

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans

Characterizing the localization and role of lin-5 and era-1 mRNAs in early C. elegans embryos

Mechanisms of differential centriole inheritance in C. elegans

Evolutionary dynamics of coding and non-coding transcriptomes