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Alamandine abrogates neutrophil degranulation in atherosclerotic mice

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Publications associées (30)

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Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Freddy Radtke, Etienne Meylan, Nadine Fournier, Amber Dawn Bowler, Justine Pascual, Anita Bodac

Elevated peripheral blood and tumor-infiltrating neutrophils are often associated with a poor patient prognosis. However, therapeutic strategies to target these cells are difficult to implement due to the life-threatening risk of neutropenia. In a genetica ...

Springernature2024

Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme

Florian Maria Wurm

Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, i ...

Frontiers Media Sa2024

Distinguishing Immunologic and Behavioral Effects of Vaccination

Mats Julius Stensrud

The interpretation of vaccine efficacy estimands is subtle, even in randomized trials designed to quantify the immunologic effects of vaccination. In this article, we introduce terminology to distinguish between different vaccine efficacy estimands and cla ...

Lippincott Williams & Wilkins2024

Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

Natasha Ella Samson

Inflammation stands as a dynamic and intricate biological process, promoting vital defence mechanisms against harmful stimuli, including infections and injuries, to drive pathogen clearance and healing. On one hand, these responses can manifest acutely and ...

EPFL2024

Interpretable Inflammation Landscape of Circulating Immune cells

Francesco Craighero

Inflammation is a biological phenomenon involved in a wide variety of physiological and pathological processes. Although a controlled inflammatory response is beneficial for restoring homeostasis, it can become unfavorable if dysregulated. In recent years, ...

2023

Numerical simulation of immiscible incompressible viscous, viscoelastic and elastic multiphase flows

Léo Aurélio Diserens

A unified numerical framework is presented for the modelling of multiphasic viscoelastic and elastic flows. The rheologies considered range from incompressible Newtonian or Oldroyd-B viscoelastic fluids to Neo-Hookean elastic solids. The model is formulate ...

EPFL2023

Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions

Atherosclerosis is a complex disease altering vasculature morphology, and subsequently flow, with progressive plaque formation, mural disruption, and lumen occlusion. Determination of clinically-relevant plaque components-particularly calcium, lipid, and f ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies

The bacterium Streptococcus pyogenes is a common cause of both mild and severe human diseases resulting in substantial morbidity and mortality each year. No vaccines are available, and our understanding of the antibody response to this human pathogen is st ...

AMER SOC MICROBIOLOGY2022

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis

Lydia Aslanidou

Atherosclerosis is a lipid driven chronic inflammatory disease that is characterized by the formation of plaques at predilection sites. These predilection sites (side branches, curved segments, and bifurcations) have often been associated with disturbed sh ...

ELSEVIER SCI LTD2021

Quantifying the transition of impact mechanisms of geophysical flows against flexible barrier

Flexible barriers have been increasingly used worldwide for mitigating natural hazards involving various geophysical flows. The analysis and design of flexible barriers need to distinguish two major impact mechanisms, runup and pile-up, which remain poorly ...

ELSEVIER2021

A plane‐strain hydraulic fracture driven by a shear‐thinning Carreau fluid

Brice Tanguy Alphonse Lecampion

We study the propagation of a plane‐strain hydraulic fracture driven by a shear thinning fluid following a Carreau rheology. We restrict to the impermeable medium case and quantify in details the impact on fracture growth of the shear‐thinning properties o ...

2021

Large particle segregation in two-dimensional sheared granular flows

Christophe Ancey, Tomás Alfredo Trewhela Palacios

We studied the segregation of single large intruder particles in monodisperse granular materials. Experiments were carried out in a two-dimensional shear cell using different intruder and media diameters, whose quotient defined a size ratio R that ranged f ...

2021

Shear Response of Wet Weak Carbonate Rock/Grout Interfaces Under Cyclic Loading

Eleni Stavropoulou

The development and construction of offshore wind farms requires the correct estimation of the friction that can be mobilised at the rock/grout interface. In conventional studies, the shear behaviour of a joint is usually investigated with laboratory tests ...

2021

Particle-size segregation and rheology coupling in dense granular flows

Tomás Alfredo Trewhela Palacios

Dense granular flows -debris or pyroclastic flows, avalanches, granular flows in heaps, silos or rotating drums-are ubiquitous to many natural and industrial processes. Their grain composition is often polydisperse, with particles differing in shape, size ...

EPFL2021

Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Cardiotrophin-1 (CT-1) is associated with cardiovascular (CV) diseases. We investigated the effect of CT-1 deficiency in the development and progression of atherosclerosis in double knockout Apoe(-/-)ct-1(-/-) mice. Apoe(-/-) C57Bl/6 or Apoe(-/-)ct-1(-/-) ...

Nature Research2020

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

Claudia Melcarne

The use of modern molecular biology tools and simple but powerful tractable model organisms such as Drosophila has contributed significantly to our recent advances in the innate immunity field, notably phagocytosis. Since 2001, many phagocytic transmembran ...

EPFL2020

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae

Nicola Harris, Beatrice Volpe, Tiffany Babette Angélique Bouchery, Julia Esser-von Bieren, Kathleen Shah

Helminth infection represents a major health problem causing approximately 5 million disability-adjusted life years worldwide. Concerns that repeated anti-helminthic treatment may lead to drug resistance render it important that vaccines are developed but ...

WILEY2020

Experimental studies of hydro-mechanical couplings in Enhanced Geothermal Reservoirs

Mateo Alejandro Acosta

Enhanced Geothermal Systems (EGS) allow for worldwide geothermal electricity production. They target deep (3-5 km), fractured rock reservoirs whose permeability is artificially increased through hydraulic stimulations (fluid injections). The injections mod ...

EPFL2020

Hydraulic Transport Through Calcite Bearing Faults With Customized Roughness: Effects of Normal and Shear Loading

Marie Estelle Solange Violay, Mateo Alejandro Acosta

Understanding fluid flow in rough fractures is of high importance to large scale geologic processes and to most anthropogenic geo‐energy activities. Here we conducted fluid transport experiments on Carrara marble fractures with a novel customized surface t ...

2020

Durable and controlled depletion of neutrophils in mice

Etienne Meylan, Julien Robert Rémi Faget, Gael Luis Boivin, Caroline Anne-Lyse Contat, Aspasia Gkasti, Pierre-Benoit Bernard Ancey, Justine Pascual, Jessica Christine Vazquez

Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective ...

Nature Research2020