Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices

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We report the development of a continuous-wave and pulsed X-band electron spin resonance (ESR) spectrometer for the study of spins on ordered surfaces down to cryogenic temperatures. The spectrometer operates in ultra-high vacuum and utilizes a half-wavele ...

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Redox homeostasis is a key factor in maintaining cellular function and health. The main determinant of the intracellular redox potential is ubiquitous glutathione (GSH) together with its oxidized dimer (GSSG). Importantly, both redox equilibrium and GSH ho ...

Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor (SNARE) proteins catalyze the fusion process of vesicles with target membranes in eukaryotic cells. To do this, they assemble in a zipper-like fashion into stable complexes between the m ...

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2 ' 3 '-cyclic GMP-AMP (cGAMP)1-7. The indiscriminate activity of cGAS towards DNA d ...

The transforming growth factor-beta (TGF-beta) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells indirectly imped ...

Neural decoding of the visual system is a subject of research interest, both to understand how the visual system works and to be able to use this knowledge in areas, such as computer vision or brain-computer interfaces. Spike-based decoding is often used, ...

The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

The observations from the Dark Energy Spectroscopic Instrument (DESI) will significantly increase the numbers of known extremely metal-poor stars by a factor of similar to 10, improving the sample statistics to study the early chemical evolution of the Mil ...

In the last decade, organoid technology has become a cornerstone in cancer research. Organoids are long-term primary cell cultures, usually of epithelial origin, grown in a three-dimensional (3D) protein matrix and a fully defined medium. Organoids can be ...

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In this article, we consider decentralized optimization problems where agents have individual cost functions to minimize subject to subspace constraints that require the minimizers across the network to lie in low-dimensional subspaces. This constrained fo ...

Designing turbocompressors is a complex and challenging task, as it involves balancing conflicting objectives such as efficiency, stability, and robustness against manufacturing deviations. This paper proposes an integrated design methodology for turbocomp ...

Native reactive electrophile species (RES) such as 4-hydroxynonenal (HNE) act as cellular signals through covalent modification of kinetically-privileged electrophile sensor proteins. Research efforts in the field focus mainly on identifying these sensor p ...

Implanted brain electrodes provide a unique way of electrically interfacing with individual neurons in vivo. However, chronic recording or stimulating capabilities of neural implants are often impaired by a strong immune response resulting in a fibrous sca ...

Activin-A is a Transforming Growth Factor-B (TGFB)-related cytokine that regulates various biological processes including cell proliferation and differentiation through autocrine, paracrine or endocrine signaling. Activin-A expression is upregulated in mul ...

Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices

Chattez avec Graph Search

Protein Kinase C Promotes Peroxisome Biogenesis and Peroxisome-endoplasmic Reticulum Interaction

Controlled Sensing of User-Defined Aptamer-Based Targets Using Scanning Ionic Conductance Spectroscopy

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Live-cell imaging powered by computation

A continuous-wave and pulsed X-band electron spin resonance spectrometer operating in ultra-high vacuum for the study of low dimensional spin ensembles

Random matrix methods for high-dimensional machine learning models

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

A look beyond the QR code of SNARE proteins

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

Predicting Visual Stimuli From Cortical Response Recorded With Wide-Field Imaging in a Mouse

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

GTC Follow-up Observations of Very Metal-poor Star Candidates from DESI

Next-Generation Modeling of Cancer Using Organoids

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

Quantization for Decentralized Learning Under Subspace Constraints

An Integrated Approach to Designing Robust Turbocompressors on Gas Bearings Through Surrogate Modeling and Constrained Multi-Objective Optimization

Towards Uncovering the Mechanisms of Electrophile Sensing and Signaling

Engineering Hydrogel-coated Neural Interfaces for Chronic Deep Brain Recording

Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma