Spontaneous aminoacylation of a RNA sequence containing a 3'-terminal 2'-thio-adenosine

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Transposable elements (TEs) are genetic units capable of spreading within the genomes of their host. TEs contribute a readily recognizable 45% of the human DNA, reflecting in part their co-option for some as source of protein-coding sequences, for others a ...

Since most dominant human mutations are single nucleotide substitutions(1,2), we explored gene editing strategies to disrupt dominant mutations efficiently and selectively without affecting wild-type alleles. However, single nucleotide discrimination can b ...

The intrinsic high entropy metadata, known as quality scores, are largely the cause of the substantial size of sequence data files. Yet, there is no consensus on a viable reduction of the resolution of the quality score scale, arguably because of collatera ...

Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by the genomes of higher vertebrates, and many act with the heterochromatin‐inducing KAP1 as repressors of transposable elements (TEs) during early embryogene ...

High-throughput sequencing of RNA molecules has enabled the quantitative analysis of gene expression at the expense of storage space and processing power. To alleviate these prob- lems, lossy compression methods of the quality scores associated to RNA sequ ...

KAP1 is an enigmatic regulatory protein, first described some twenty years ago, shown to be involved in multiple and diverse cellular functions. Specifically, it mediates tasks critical to cell growth and differentiation, pluripotency, apoptosis, gene sile ...

The capability to rapidly design proteins with novel functions will have a significant impact on medicine, biotechnology and synthetic biology. Synthetic genes are becoming a commodity, but integrated approaches have yet to be developed that take full adva ...

High-throughput sequencing was previously applied to phage-selected peptides in order to gain insight into the abundance and diversity of isolated peptides. Herein we developed a procedure to efficiently compare the sequences of large numbers of phage-sele ...

More than 100 modified nucleosides have been found in naturally occurring RNA sequences. These modifications are involved in the correct folding, in the maintenance of the reading frame during translation and in the proper interaction with enzymes and prot ...

Spontaneous aminoacylation of a RNA sequence containing a 3'-terminal 2'-thio-adenosine

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Beyond silence : a functional and evolutionary study of KRAB zinc finger proteins

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

Toward a Dynamic Threshold for Quality-Score Distortion in Reference-Based Alignment

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification

Lossy compression of quality scores in differential gene expression: A first assessment and impact analysis

Genomic targets and molecular partners of the chromatin regulator KAP1

Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering

Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides

Synthesis of modified nucleosides for the incorporation into tRNAs