In the pursuit of the fear engram: identification of neuronal circuits underlying the treatment of anxiety disorder

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Background: Cognitive behavioral therapy (CBT) is the current standard treatment for chronic severe tinnitus; however, preliminary evidence suggests that real-time functional MRI (fMRI) neurofeedback therapy may be more effective. Purpose: To compare the e ...

This chapter offers a new view of post-Soviet Ukrainain literary memory as expressed in varous texts, redefining the role of clashing narratives of the past under the divisive political and social conditions of upheavals, crises, and military conflicts. Th ...

This study aims to determine whether 1) individuals with treatment-resistant schizophrenia display early cognitive impairment compared to treatment-responders and healthy controls and 2) N-methyl-D-aspartate-receptor hypofunction is an underlying mechanism ...

The subject of the book is the specificity of social, national-cultural and historical self-consciousness of the "educated class" of the former Russian Empire and the former Soviet Union. The phenomenon of "intelligentsia" is considered in the spirit of V ...

Electric vehicles (EVs) are becoming more popular due to environmental consciousness. The limited availability of charging stations (CSs), compared to the number of EVs on the road, has led to increased range anxiety and a higher frequency of CS queries du ...

Traumatic events generate some of the most enduring memories, yet little is known about how long-lasting fear memories can be attenuated. In this review, we collect the surprisingly sparse evidence on remote fear memory attenuation from both animal and hum ...

The recollection of sensory information and subjective experience related to a personal past event depends on our episodic memory (EM). At the neural level, EM retrieval is linked with the reinstatement of hippocampal activity thought to recollect the sens ...

Empirical evidence shows that memories that are frequently revisited are easy to recall, and that familiar items involve larger hippocampal representations than less familiar ones. In line with these observations, here we develop a modelling approach to pr ...

Over the course of a lifetime, the human brain acquires an astonishing amount of semantic knowledge and autobiographical memories, often with an imprinting strong enough to allow detailed information to be recalled many years after the initial learning exp ...

Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...

A painful episode can lead to a life-long increase in an individual's experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are unclear because fear can both suppress and enhan ...

How the 'what', 'where', and 'when' of past experiences are stored in episodic memories and retrieved for suitable decisions remains unclear. In an effort to address these questions, the authors present computational models of neural networks that behave l ...

Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...

Alterations of the limbic system may be present in the chronic phase of SARS-CoV-2 infection. Our aim was to study the long-term impact of this disease on limbic system-related behaviour and its associated brain functional connectivity, according to the se ...

Memory devices have returned to the spotlight due to increasing interest in using in-memory computing architectures to make data-driven algorithms more energy-efficient. One of the main advantages of this architecture is the efficient performance of vector ...

Machine learning and data processing algorithms have been thriving in finding ways of processing and classifying information by exploiting the hidden trends of large datasets. Although these emerging computational methods have become successful in today's ...

Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...

This short essay illustrates the role of the business archive in the transmission and maintenance of contemporary industrial culture, with a focus on the company town of Dalmine. In the context of Dalmine, the business archive managed by the Fondazione Dal ...

Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder worldwide, and the current treatment options for these patients remain limit ...

A memory engram is thought to be the physical substrate of the memory trace within the brain, which is generally depicted as a neuronal ensemble activated by learning to fire together during encoding and retrieval. It has been postulated that engram cell e ...

In the pursuit of the fear engram: identification of neuronal circuits underlying the treatment of anxiety disorder

Chattez avec Graph Search

Functional MRI Neurofeedback Outperforms Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial

Ukrainian Literary Imaginaries of Past after 1991: From Substitution to Restoration?

Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

Цена автономии^ Университет, «украинский вопрос», (не)академическая память в долгом двадцатом веке [The Price of Autonomy: University, the "Ukrainian question," (un)academic memory In the long twentieth century]

A Privacy-Preserving Querying Mechanism with High Utility for Electric Vehicles

Face your fears: attenuating remote fear memories by reconsolidation-updating

Bodily self-consciousness as a framework to link sensory information and self-related components of episodic memory: behavioral, neuroimaging, and clinical evidence

A dynamic attractor network model of memory formation, reinforcement and forgetting

A theory of memory consolidation and synaptic pruning in cortical circuits

Plasticity of sensory representations in the posterior insular cortex during fear learning

Prefrontal engrams of long-term fear memory perpetuate pain perception

Computational models of episodic-like memory in food-caching birds

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

Markers of limbic system damage following SARS-CoV-2 infection

How to Achieve Large-Area Ultra-Fast Operation of MoS 2 Monolayer Flash Memories?

2D Nanosystems: Applications of 2D Semiconductors for In-Memory Computing

Engram cell connectivity as a mechanism for information encoding and memory function

When the industry built the city: business archives, memory and community in a contemporary company town

Glucocorticoid-based pharmacotherapies preventing PTSD

Tissue clearing applications in memory engram research