Photoresponsive Nanocarriers Based on Lithium Niobate Nanoparticles for Harmonic Imaging and On-Demand Release of Anticancer Chemotherapeutics

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Publications associées (31)

Photocontrolled release of the anticancer drug chlorambucil with caged harmonic nanoparticles

Jean-Pierre Wolf, Sandrine Gerber, Luigi Bonacina, Raphaël Jovita De Matos, Jérémy Vuilleumier

While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy ...

Wiley-VHCA AG2020

Localized Photon Lasing in a Polaritonic Lattice Landscape

Daniel Oberli, Marcia Portella Oberli, Fauzia Jabeen, Morteza Navadeh Toupchi

Periodic photonic structures have attracted much interest due to their versatility for controlling light propagation. The dispersion of photon modes in photonic lattices exhibits an energy band structure analo-gous to the electronic one in crystals. An imp ...

American Physical Society (APS)2020

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

Li Tang, Kewen Lei

T cell-based cancer immunotherapy has achieved great success in the clinic; however, only a small fraction of patients respond to this therapy. Strategies to specifically and safely augment anticancer activity through controlled delivery of T cell supporti ...

2020

Wavefront shaping and deep learning in fiber endoscopy

Eirini Kakkava

Fiber endoscopy plays an important role in the clinical diagnosis and treatment processes involved in modern medicine. Thin fiber probes can relay information from confined places in the human body that are inaccessible for conventional bulky microscopes. ...

EPFL2020

Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices

Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Riccardo Rizzo

Three-dimensional (3D) control over the placement of bioactive cues is fundamental to understand cell guidance and develop engineered tissues. Two-photon patterning (2PP) provides such placement at micro- to millimeter scale, but nonspecific interactions b ...

Wiley-V C H Verlag Gmbh2020

Functionalization of second harmonic generation nanoparticles for theranostic applications

Jérémy Vuilleumier

Nowadays, cancer is one of the leading causes of death in developed countries. The actual medical tools to detect cancer at early stage suffer to their low sensitivity. The design of multimodal nanodevices for in vivo imaging offers the perspective of canc ...

EPFL2019

Synthetic 3D PEG-Anisogel Tailored with Fibronectin Fragments Induce Aligned Nerve Extension

Matthias Lütolf, Jeffrey Alan Hubbell, Delphine Lorraine Perle Blondel

An enzymatically cross-linked polyethylene glycol (PEG)-based hydrogel was engineered to promote and align nerve cells in a three-dimensional manner. To render the injectable, otherwise bioinert, PEG-based material supportive for cell growth, its mechanica ...

American Chemical Society2019

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

In Situ Observation of Coulomb Fission of Individual Plasmonic Nanoparticles

Marcel Drabbels, Ulrich Lorenz, Pavel Olshin, Jonathan Mark Voss

Reshaping plasmonic nanoparticles with laser pulses has been extensively researched as a tool for tuning their properties. However, in the absence of direct observations of the processes involved, important mechanistic details have remained elusive. Here, ...

2019

Optical projection tomography for whole organ imaging

David Nguyen

In the past twenty years, far-reaching studies of molecular and cellular processes have reached a milestone in their maturation, and the knowledge from these studies was ready to apply at higher organizational levels. At that time, rodent models were long ...

EPFL2019

Physics of Dissipative Kerr Solitons in Optical Microresonators and Application to Frequency Synthesis

Erwan Guillaume Albert Lucas

Optical-frequency combs, that is spectra of equidistant coherent optical lines, have revolutionized the precision measurements of time and frequency. In 2007 a new method to generate optical frequency combs was discovered. In contrast to conventional gener ...

EPFL2019

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