IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

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This paper introduces Wireless IoT-based Noise Cancellation (WINC) which defines a framework for leveraging a wireless network of IoT microphones to enhance active noise cancellation in noise-canceling headphones. The IoT microphones forward ambient noise ...

Retinoblastoma, while relatively rare, stands as the most prevalent intraocular cancer. In Switzerland, the survival rate approaches 100%, but it drops to less than 50% in low-income countries. The current treatment options for retinoblastoma rely on a lim ...

Simple Summary Zebrafish (Danio rerio) younger than five days post fertilization are not protected by legislation, and protocols for their euthanasia are poorly explored. In the present paper, we assess the euthanasic efficacy of anesthetic overdose, hypot ...

COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the prefe ...

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesi ...

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Such contact-less devices provide several advantages such as better dose control, lateral and depth localisation, lower collateral damage than ...

Direct and online continuous monitoring of anaesthetic intake by the patient's blood stream improves practices in the critical procedure of anaesthesia. Several systems have been proposed to address this challenge. Electrochemical techniques are highly app ...

Despite the huge expansion in recent years of sweat sensing and wearable technologies, several challenges are still open, including poor sample collection, separate sampling and analysis, low multi-sensing capabilities and materials toxicity. In this work, ...

With the growth of personalized medicine and e-Health, there has been an increasing interest in the development of accurate sensing systems able to support this healthcare revolution for both in- and off-hospital monitoring. Remote biosensing devices can d ...

Monitoring of patient response to the anaesthetic drugs is an attractive improvement for achieving a correct balance of sedation level, increasing the chance of success in the right procedure of anaesthesia. Nowadays, there are no commercial tools able to ...

The live demonstration presents the innovative concept of a portable pen-device able to sense anaesthetic compounds over time for improved anaesthesiology practice. A custom Printed Circuit Board (PCB) manage in the event-based quasi-digital domain the sam ...

Induction of anesthesia with propofol is a largely adopted technique in hospital environments. The correct dosage of this compound is essential to avoid under- or over-anesthesia that may result in serious side-effects. Therefore, in clinical settings, lon ...

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

In this work, we present a novel electrochemical cleaning procedure for long-term electrochemical monitoring of propofol by using boron-doped diamond (BDD) and pencil graphite electrode (PGE). Propofol is an anesthetic that is widely used for long-lasting ...

Pain is both a major clinical and economic problem, affecting more people than diabetes, heart disease, and cancer combined. While a variety of prescribed or over-the-counter (OTC) medications are available for pain management, opioid medications, especial ...

Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...

Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated ...

BACKGROUND: An auditory perceptual learning paradigm was used to investigate whether implicit memories are formed during general anesthesia. METHODS: Eighty-seven patients who had an American Society of Anesthesiologists physical status of I-III and were s ...

In order to improve the efficacy and safety of treatments, drug dosage needs to be adjusted to the actual needs of each patient in a truly personalized medicine approach. Key for widespread dosage adjustment is the availability of point-of-care devices abl ...

IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

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WINC: A Wireless IoT Network for Multi-Noise Source Cancellation

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

A Multi-Site Assessment of Anesthetic Overdose, Hypothermic Shock, and Electrical Stunning as Methods of Euthanasia for Zebrafish (Danio rerio) Embryos and Larvae

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Smart Portable Pen for Continuous Monitoring of Anaesthetics in Human Serum With Machine Learning

Laser-induced liquid micro-jets for drug delivery

Pencil Graphite Needle-Shaped Biosensor for Anaesthetic Monitoring in Human Serum

Wearable multifunctional sweat-sensing system for efficient healthcare monitoring

Wearable multi-electrode platform for ion sensing

Quasi-Digital Biosensor-Interface for a Portable Pen to Monitor Anaesthetics Delivery

Live Demonstration: Quasi-Digital Portable Pen to Monitor Anaesthetics Delivery

Raspberry-Pi based system for propofol monitoring

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Cleaning strategy for carbon-based electrodes: Long-term propofol monitoring in human serum

Designing Safer Analgesics via mu-Opioid Receptor Pathways

Energy metabolism in the rat cortex under thiopental anaesthesia measured

Allosteric cross-talk in chromatin can mediate drug-drug synergy

Anesthesia prevents auditory perceptual learning

Label-Free Detection of Tobramycin in Serum by Transmission-Localized Surface Plasmon Resonance