Publications associées à Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

Publications associées (9)

The SNP-Based Profiling of Montecristo Feral Goat Populations Reveals a History of Isolation, Bottlenecks, and the Effects of Management

The Montecristo wild goat is an endangered feral population that has been on the homonymous island in the Tuscan Archipelago since ancient times. The origins of Montecristo goats are still debated, with authors dating their introduction either back to Neol ...

MDPI2022

A cell fitness selection model for neuronal survival during development

Gioele La Manno

Developmental cell death plays an important role in the construction of functional neural circuits. In vertebrates, the canonical view proposes a selection of the surviving neurons through stochastic competition for target-derived neurotrophic signals, imp ...

Nature Research2019

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting

Liliane Glauser, Elpida Tsika

Mutations in a number of genes cause familial forms of Parkinson's disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) and parkin genes. In this study, we identify a novel functional interaction between parkin and VPS35. W ...

Oxford University Press2018

Convergent genomic signatures of domestication in sheep and goats

Stéphane Joost

The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as more domestic species become genome-enabled. Before becoming established worldwide, sheep and goats were domesticated in the ...

Nature Publishing Group2018

The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals

Jacques Fellay, Istvan Bartha

Systemic immune activation, a major determinant of human immunodeficiency virus (HIV) disease progression, is the result of a complex interplay between viral replication, dysregulation of the immune system, and microbial translocation due to gut mucosal da ...

Oxford University Press2015

De-anonymizing Genomic Databases Using Phenotypic Traits

Jean-Pierre Hubaux, Erman Ayday, Mathias Jacques Jean-Marc Humbert, Kévin Clément Huguenin, Joachim Ludovic Hugonot

People increasingly have their genomes sequenced and some of them share their genomic data online. They do so for various purposes, including to find relatives and to help advance genomic research. An individual's genome carries very sensitive, private inf ...

2015

Pass-by noise acoustic sensing for estimating speed and wheelbase length of two-axle vehicles

Hervé Lissek, Jean-Marc Odobez, Xavier Falourd, Patrick Marmaroli

This paper focuses on acoustic road traffic monitoring and looks, more specifically, into the problem of speed and wheelbase length estimation of two-axle vehicles as they pass by. It is known that both front and rear axle trajectories may be dissociated u ...

2013

Functional Analysis of PGRP-LA in Drosophila Immunity

Bruno Lemaitre, Juan Camilo Paredes Escobar

PeptidoGlycan Recognition Proteins (PGRPs) are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet unc ...

Public Library of Science2013

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

Johan Auwerx, Kristina Schoonjans

BACKGROUND & AIMS: The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear receptors are transcription factors funct ...

2010