Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

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Publications associées (29)

Characterization of Ligand Shell for Mixed-Ligand Coated Gold Nanoparticles

Francesco Stellacci, Quy Ong Khac, Zhi Luo

Gold nanoparticles owe a large number of their properties to their ligand shell. Indeed, many researchers routinely use mixtures of ligand molecules for their nanoparticles to impart complex property sets. It has been shown that the morphology of ligand sh ...

American Chemical Society2017

Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T-2 Contrast Agent

Kurt Schenk, Henrik Moodysson Rønnow, Arash Alahgholipour Omrani, Francesco Stellacci, Randy Patrick Carney, Paulo Henrique Jacob Silva, Tamara Michael Carney, Ping Huang, Lin Yang

Nanoparticle-based magnetic resonance imaging T-2 negative agents are of great interest, and much effort is devoted to increasing cell loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, ...

American Chemical Society2017

Chelating agents as coating molecules for iron oxide nanoparticles

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin, Josefina Adriana Maria Bastiaansen

Due to their high chemical affinity towards metal ions, chelating agents (CAs) have been used for decades for water purification, but also for protection against metal intoxication and in nanomedicine as linking molecules at the surface of nanoparticles. H ...

RSC Publishing2017

High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

Francesco Stellacci, Ye Yang, Ahmet Bekdemir, Li Tang

Inorganic nanoparticles (NPs) are studied as drug carriers, radiosensitizers and imaging agents, and characterizing nanoparticle biodistribution is essential for evaluating their efficacy and safety. Tracking NPs at the single-cell level with current techn ...

Nature Publishing Group2017

Coherent Imaging of Cellular Dynamics

Miguel Sison

Mitochondrial dynamics refers to the processes of fusion, fission, and transport that aid mitochondria in accomplishing their many roles; including ATP production, oxygen sensing, and homeostasis. Due to their involvement in numerous essential cellular act ...

EPFL2017

Acetylene Oligomerization over Pd Nanoparticles with Controlled Shape: A Parahydrogen-Induced Polarization Study

Lioubov Kiwi, Rocio Micaela Crespo Quesada

Substantial signal enhancements achieved by using parahydrogen in catalytic hydrogenations are powerful tools for mechanistic studies of chemical reactions involving molecular H-2. Potentially, this technique can be extended to other reaction classes, prov ...

American Chemical Society2016

Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T

Rolf Gruetter, Hongxia Lei

Glioma models have provided important insights into human brain cancers. Among the investigative tools, MRI has allowed their characterization and diagnosis. In this study, we investigated whether diffusion MRI might be a useful technique for early detecti ...

Wiley-Blackwell2016

Gold nanoparticles functionalised with fast water exchanging Gd3+ chelates: linker effects on the relaxivity

Lothar Helm, Bibimaryam Mousavi

The relaxivity displayed by Gd3+ chelates immobilized onto gold nanoparticles is the result of the complex interplay between the nanoparticle size, the water exchange rate and the chelate structure. In this work we study the effect of the length of omega-t ...

Royal Society of Chemistry2015

Response to "Critical Assessment of the Evidence for Striped Nanoparticles"

Francesco Stellacci, Quy Ong Khac

Stirling et al., (10.1371/journal.pone.0108482) presented an analysis on some of our publications on the formation of stripe-like domains on mixed-ligand coated gold nanoparticles. The authors shed doubts on some of our results however no valid argument is ...

Public Library of Science2015

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