Amino Acids and Their Biological Derivatives Modulate Protein-Protein Interactions in an Additive Way

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The 70 kDa heat shock protein (Hsp70) chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) coevolved with Hsp70s to trigger ATP hydrolysis and catalytically upload various substrate polypeptides in ne ...

We introduce an infrared metasurface sensor based on plasmonic surface-enhanced infrared absorption spectroscopy combined with immunoassay, which detects alpha-synuclein, an early structural biomarker protein for neurodegenerative diseases with clinical sp ...

Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic and structural data increase. This k ...

Interactions between food and saliva govern complex mouthfeel perceptions such as astringency. Herein, we present a study of the interactions of salivary proteins with the main pea protein fractions that are obtained by isoelectric and salt precipitation ( ...

Peptides constitute an important class of drugs for the treatment of multiple metabolic, ontological, and neurodegenerative diseases, and several hundred novel therapeutic peptides are currently in the preclinical and clinical stages of development. Howeve ...

Cerebral metabolism is compartmentalized between neurons and glia. Although glial glycolysis is thought to largely sustain the energetic requirements of neurotransmission while oxidative metabolism takes place mainly in neurons, this hypothesis is matter o ...

The mechanisms that ensure centrosome duplication are poorly understood. In Caenorhabditis elegans, ZYG-1, SAS-4, SAS-5 and SPD-2 are required for centriole formation. However, it is unclear whether these proteins have functional homologues in other organi ...

Eight new seven-membered ring iminoalditols, displaying an amino group and a hydroxymethyl group on the ring, have been synthesized from D-arabinose via epoxidation of a protected azacycloheptene and subsequent nucleophilic opening. Three of them show a po ...

Amino Acids and Their Biological Derivatives Modulate Protein-Protein Interactions in an Additive Way

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Autorepression of yeast Hsp70 cochaperones by intramolecular interactions involving their J-domains

Deep learning augmented nanoplasmonic infrared sensor for structural protein biomarker-based detection of neurodegenerative diseases

De novo design of protein interactions with learned surface fingerprints

Difference in astringency of the main pea protein fractions

Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo

Compartmentalized Cerebral Metabolism of [1,6-(13)C]Glucose Determined by in vivo (13)C NMR Spectroscopy at 14.1 T

SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells

New 1-amino-1-deoxy- and 2-amino-2-deoxy-polyhydroxyazepanes: synthesis and inhibition of glycosidases