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Protein semisynthesis and total synthesis approaches to elucidate the role of Alpha-Synuclein post-translational modifications

Bruno Claude Daniel Fauvet
2014
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Bruno Claude Daniel Fauvet
2014
Theses

Source officielle

Publications associées (11)

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https://infoscience.epfl.ch/entities/publication/571e08b4-ada1-466d-a48e-2f5e97c0d4fc

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Publications associées (11)

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MagIC beads for scarce macromolecules

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Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples. ...

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Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders

Hilal Lashuel, Melek Firat Altay

Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Parkinson's disease (PD), Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB), and in oligodendrocytes in multiple system atrophy (MSA ...

BMC2022

The promise of multi-omics approaches to discover biological alterations with clinical relevance in Alzheimer's disease

Loïc Dayon

Beyond the core features of Alzheimer's disease (AD) pathology, i.e. amyloid pathology, tau-related neurodegeneration and microglia response, multiple other molecular alterations and pathway dysregulations have been observed in AD. Their inter-individual v ...

FRONTIERS MEDIA SA2022