The Relationship between PSD-95 Clustering and Spine Stability In Vivo

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The nematode Caenorhabditis elegans offers a uniquely tractable model for studying the relationships between neuronal activity, connectivity, and behavior. Despite its simplicity, key questions remain about how information flows through its nervous system ...

Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly mani ...

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...

Over the course of a lifetime, the human brain acquires an astonishing amount of semantic knowledge and autobiographical memories, often with an imprinting strong enough to allow detailed information to be recalled many years after the initial learning exp ...

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

Recent developments in experimental techniques have enabled simultaneous recordings from thousands of neurons, enabling the study of functional cell assemblies. However, determining the patterns of synaptic connectivity giving rise to these assemblies rema ...

Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...

The fundamental role of any neuron within a network is to transform complex spatiotemporal synaptic input patterns into individual output spikes. These spikes, in turn, act as inputs for other neurons in the network. Neurons must execute this function acro ...

We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...

Neuronal endoplasmic reticulum (ER) appears continuous throughout the cell. Its shape and continuity are influenced by ER-shaping proteins, mutations in which can cause distal axon degeneration in Hereditary Spastic Paraplegia (HSP). We therefore asked how ...

Neurons primarily communicate through release of neurotransmitter from presynaptic specialisations along their axonal arborisations. In order to understand the functional role of a specific neuron, it is therefore of great interest to know the structure of ...

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

Developing spinal circuits generate patterned motor outputs while many neurons with high membrane resistances are still maturing. In the spinal cord of hatchling frog tadpoles of unknown sex, we found that the firing reliability in swimming of inhibitory i ...

An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...

Dopamine synapses play a crucial role in volitional movement and reward-related behaviors, while dysfunction of dopamine synapses causes various psychiatric and neurological disorders. Despite this significance, the true biological nature of dopamine synap ...

Planning and execution of voluntary movement depend on the contribution of distinct classes of neurons in primary motor and premotor areas. However, timing and pattern of activation of GABAergic cells during specific motor behaviors remain only partly unde ...

The Relationship between PSD-95 Clustering and Spine Stability In Vivo

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Behaviorally Relevant Information Content in Interneuron Activity

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

Subcortical correlates of consciousness with human single neuron recordings

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Principles of Network Plasticity in Neocortical Microcircuits

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

Plasticity of sensory representations in the posterior insular cortex during fear learning

A theory of memory consolidation and synaptic pruning in cortical circuits

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Cortical cell assemblies and their underlying connectivity: an in silico study

Engram cell connectivity as a mechanism for information encoding and memory function

Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs

Striatal Dopamine Signals and Reward Learning

Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics

Axonal projections from mouse whisker-related sensory cortex

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Mechanisms Underlying the Recruitment of Inhibitory Interneurons in Fictive Swimming in Developing Xenopus laevis Tadpoles

Neuronal correlates of goal-directed sensorimotor transformation in sensory, motor and higher-order cortical areas

GABAergic-like dopamine synapses in the brain

Fast-Spiking Interneurons of the Premotor Cortex Contribute to Initiation and Execution of Spontaneous Actions