Predictive Engineering the Membrane Composition of Neocortical Neurons

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The nematode Caenorhabditis elegans offers a uniquely tractable model for studying the relationships between neuronal activity, connectivity, and behavior. Despite its simplicity, key questions remain about how information flows through its nervous system ...

Transient receptor potential (TRP) melastatin 4 (TRPM4) protein is a calcium-activated monovalent cation channel associated with various genetic and cardiovascular disorders. The anthranilic acid derivative NBA is a potent and specific TRPM4 inhibitor, but ...

Metal ions are indispensable cofactors for many proteins and play crucial roles in numerous biological processes, yet the computational design of metalloproteins and the optimization of metal coordination sites poses significant challenges due to the comp ...

Background: Eating disorders (EDs) are serious psychiatric disorders characterized by impairments in neurocognition and altered brain structure. To date the majority of studies have investigated these in acutely ill or recovered individuals. Studying child ...

An important function of the neocortex is to compare sensory feedback stimuli with internal predictions of the outside world and evoke mismatch responses to deviations, thus allowing expectations to be updated. The mechanisms behind sensory feedback mismat ...

Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples. ...

A method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject includes: (a) determining the protein level of at least one protein in the sample of isolated cholesterol-rich lipoprotein nanoparti ...

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

This dataset contains images (TIFF image data) of brain juvenile rats Wistar Han (P14) scanned immunostained slides by using an automated slide scanner (Olympus, VS120-L100, GER) equipped with a UPLSAPO 20x/0.75 air objective (Olympus, GER) and a Pike F5 ...

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Human babies have a natural desire to interact with new toys and objects, through which they learn how the world around them works, e.g., that glass shatters when dropped, but a rubber ball does not. When their predictions are proven incorrect, such as whe ...

The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine learni ...

Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the epigenetic mechanisms underlying human cell diversity has been di ...

Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...

Implanted medical devices (IMDs) have been widely developed to support the monitoring and recording of biological data inside the body or brain. Wirelessly powered IMDs, a subset of implantable electronics, have been proposed to eliminate the limitations r ...

Proprioception tells the brain the state of the body based on distributed sensors in the body. However, the principles that govern proprioceptive processing from those distributed sensors are poorly understood. Here, we employ a task-driven neural network ...

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...

Recent research shows prominent effects of pregnancy and the parenthood transition on structural brain characteristics in humans. Here, we present a comprehensive study of how parental status and number of children born/fathered links to markers of brain a ...

Predictive Engineering the Membrane Composition of Neocortical Neurons

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Behaviorally Relevant Information Content in Interneuron Activity

Identification of a binding site for small molecule inhibitors targeting human TRPM4

Engineering of stable and functional metalloproteins using evolutionary computation, deep learning and simulation

Neurobiology and Cognition in Girls at High-risk of Eating Disorders: Exploring Imaging-derived Trait Markers

Top-down modulation of sensory processing and mismatch in the mouse posterior parietal cortex

MagIC beads for scarce macromolecules

Cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Orthogonally Functionalizable Redox-Responsive Polymer Brushes: Catch and Release Platform for Proteins and Cells

Subcortical correlates of consciousness with human single neuron recordings

Nissl_5, Raw images for Machine learning for histological annotation and quantification of cortical layers

White adipose tissue distribution and amount are associated with increased white matter connectivity

Seeking the new, learning from the unexpected: Computational models of surprise and novelty in the brain

Computational drug development for membrane protein targets

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Integrated Wireless Power, Data Communication, and Thermal Sensing System for Autonomous Multisite Brain Implants

Task-driven neural network models predict neural dynamics of proprioception: Neural network model weights

Multimodal transcriptomic atlases of mouse spinal cord injury

Membrane specificity of the human cholesterol transfer protein STARD4

Parental status and markers of brain and cellular age: A 3D convolutional network and classification study