Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF

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Publications associées (31)

Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy

Bernard Schneider

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of the SMN1 gene and low SMN protein levels. Although lower motor neurons are a primary target, there is evidence that peripheral organ defects contribute to SMA. Current SMA gene ther ...

2022

Synergic Effect of Dendrite-Free and Zinc Gating in Lignin-Containing Cellulose Nanofibers-MXene Layer Enabling Long-Cycle-Life Zinc Metal Batteries

Kangning Zhao, Xu Zhang, Zequan Li

Uncontrollable zinc dendrite growth and parasitic reactions have greatly hindered the development of high energy and long life rechargeable aqueous zinc-ion batteries. Herein, the synergic effect of a bifunctional lignin-containing cellulose nanofiber (LCN ...

WILEY2022

Uncovering the neural encoding of behavior in the adult Drosophila motor system

Chin-Lin Chen

One of the most important goals in neuroscience research has always been to understand how animals control their behavior. However, the long focus on the role of brain neurons in behavioral control might be missing the full story. In fact, brain-wide fluct ...

EPFL2022

Optimization and dynamic responses of an integrated fuel cell and battery system for an 800 kW ferry: A case study

Jan Van Herle, Martin Daniel Gay, Hossein Pourrahmani

The recent targets by different countries to stop the sales or registrations of internal combustion engines (ICE) have led to the further development of battery and fuel cell technologies to provide power for different applications. The main aim of this st ...

ELSEVIER2022

Robust Resource-Aware Self-Triggered Model Predictive Control

Colin Neil Jones, Yingzhao Lian, Yuning Jiang

The wide adoption of wireless devices in the Internet of Things requires controllers that are able to operate with limited resources, such as battery life. Operating these devices robustly in an uncertain environment, while managing available resources, in ...

2022

A Battery-Free Wireless Smart Sensor platform with Bluetooth Low Energy Connectivity for Smart Agriculture

Catherine Dehollain, Roberto La Rosa

Smart agriculture systems, which integrate sensors and data analysis into agricultural production processes, are increasingly proving an effective solution for reducing food production waste, yield production increase, and product quality improvement. In t ...

IEEE2022

De novo developed small cyclic peptides that are orally available

Manuel Leonardo Merz

Cyclic peptides are ring-shaped molecules that emerged as a promising class of therapeutics. While it is often difficult to find small molecule binders for challenging disease targets, cyclic peptides can bind to featureless surfaces or inhibit protein-pro ...

EPFL2022

Dissecting motor skill acquisition: Spatial coordinates take precedence

Pablo Maceira Elvira, Friedhelm Christoph Hummel, Takuya Morishita, Anne-Christine Schmid, Maximilian Jonas Wessel, Traian Popa

Practicing a previously unknown motor sequence often leads to the consolidation of motor chunks, which enable its accurate execution at increasing speeds. Recent imaging studies suggest the function of these structures to be more related to the encoding, s ...

AMER ASSOC ADVANCEMENT SCIENCE2022

Redox dual-flow battery for combined electricity storage and hydrogen production

Danick Reynard

The energy transition towards a carbon-neutral and sustainable economy is one of the greatest challenges of the 21st century to combat global warming and pollution. The decarbonization process is affecting every sector of the economy (electricity, transpor ...

EPFL2022

Photocured Nanocellulose Composites: Recent Advances

Yves Leterrier, Aigoul Schreier, Mohammed Arif Poothanari, Julien Bras

This perspective gives an overview of recent progress in thefield of photocured polymer composites based on variousforms of nanocelluloses, with a focus on cellulose nanofibrils. The manufacturing processes and performances of these nanocellulosecomposites ...

AMER CHEMICAL SOC2022

Determining patterns of post-stroke motor recovery through longitudinal multimodal MRI: A step towards patient stratification

Julia Brügger

Motivated by the need for a better understanding of post-stroke recovery and new biomarkers to improve stroke patient stratification and outcomes, this thesis investigated structure-function coupling and its role in post-stroke recovery. Furthermore, in or ...

EPFL2022

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